Biochemistry 601: Enzyme Structure and Function. Protein structure and function, enzyme kinetics and mechanisms. Prerequisites: Biochemistry 501 or equivalent, 1 semester of physical chemistry, 1 year of organic chemistry. View a more complete description.
Pharmacology 620: Eukaryotic Molecular Biology. This course focuses on the basic molecular mechanisms that regulate DNA, RNA, and protein metabolism in eukaryotic organisms. The course is intended for adv undergrads and first yr grad students with a firm knowledge of basic biochemistry. Prerequisites: Biochem 508 or equivalent. View a more complete description.
Pharmacology 625: Molecular and Environmental Toxicology I.Principles of toxicology and biochemical mechanisms of toxicity in mammalian species, including humans. Correlation between morphological and functional changes caused by toxicants in different organs of the body. Prerequisites: Biochemistry 501 and Physiology 335 or consent of instructor; Pathology 401 and Pharmacology 401 or equivalent recommended.
Pharmacology 626: Molecular and Environmental Toxicology II. A course surveying the basic methods and fundamental biochemical mechanisms of toxicity. Toxicity in mammalian organ systems, techniques for evaluating toxicity, as well as mechanisms of species specificity, and environmental interactions (with toxicant examples) are presented. Prerequisite: Env Tox 625 or consent of instructor.
Biochem 630: Cellular Signal Transduction Mechanisms (Also Pharmacology 630, Zoology 630) Fall; 3 cr. Provides a comprehensive introduction for advanced undergraduates and graduate students to the essential elements of cellular transduction mechanisms that allow signaling from the cell surface to the nucleus. Emphasis is on the synthesis of peptide signals, receptors and receptor trafficking, second messengers, protein kinase cascades, cell cycle regulation, and the regulation of transcription factors and gene transcription. Recommended prerequisites: Introductory Biochemistry (Biochem 501, or 507 and 508) and Cell Biology (Biocore 303 or Zoology 570 or Pathology 750) or consent of instructor. Instructors: Thomas Martin, Arnold Ruoho, Beth Weaver, Richard Anderson, Shigeki Miyamoto, Emery Bresnick. View a more complete description.
Oncology 675: Protein Purification. A course on the theory and practice of protein purification. Topics covered include conventional and recent protein fractionation techniques; enzyme assays, handling, and characterization; purification strategy; and overproduction of cloned gene products. The emphasis is on micro and laboratory scale purifications. Prerequisites: Biochemistry and physical chemistry or consent of instructor.
Oncology 703: Carcinogenesis and Tumor Cell Biology. Factors involved in tumor production in humans and experimental animals; biology and biochemistry of neoplasia, both in vivo and in vitro. Prerequisites: Oncology 401 or equivalent, organic chemistry, biochemistry, cell biology, virology, or consent of instructor. View a more complete description.
Pharmacology 710: Cytosolic and Nuclear Signaling Mechanisms. Biochemical basis of drug action. Overall course format involves two major activities: 1) presentations and discussion of topics in cellular signaling and 2) the development of a 5-6 page research proposal on a focused and important topic in cellular signaling.Prerequisites: Pharmacology 630, Biochem 601 or equivalent, and consent of instructor.
Pharmacology 711: Molecular Principles in Pharmacology. This 2-credit course is a Basic and Clinical Pharmacology sequence that is an introduction to the actions of drugs. This course will provide an understanding of the principles of drug action t athe molecular, cellular, organ, and whole person levels. The major classes of drugs, their mechanisms of action, indications for their use, and their adverse effects will be discussed. Topics for Pharmacology 711 include: general principles, drug dispostioin, applied pharmacokinetics, autacoid pharmacology, peripheral nervous system pharmacology, cardiovascular and renal pharmacology, chemotherapeutic agents (anticancer, antibacterial, and antifungal drugs), and immunopharmacology. Satisfactory completion of introductory courses in Biochemistry, Physiology, and Pathology is highly recommended. Students will be required to present research. View a more complete description or check out the schedule for the course.
Pathology 750: Cell and Molecular Biology. The emphasis is on our current understanding of molecular and cellular mechanisms. Where possible, human diseases are used to illustrate the outcome at the organismal level of defects in these mechanisms. Lectures will draw from the current research literature and cover topics such as cell and tissue organization, intracellular sorting, cell migration and growth.Prerequisites: Grad student or consent of instructor.
Pharmacology 875, Lecture 5: Cell Signaling and Human Disease. This course focuses on the cellular and molecular signaling basis for human diseases. This course will focus on cancer biology and primary immunodeficiencies. Exciting new advances in understanding molecular mechanisms of disease will be highlighted, including (but not limited to) discussion of: Wiscott-Aldrich Syndrome and WASP protein Ataxia Telangietasia and ATM Breast Cancer and ErbB2(Her-2), BRCA, p53, Ras, PTEN.Prerequisites: Introductory course in biochemistry, molecular biology, and genetics and consent of instructor.
Pharmacology 875, Lecture 7: Ethics in Research. The student will choose case studies of a real issue or situation in scientific ethics, for presentation in the ethics seminar. Prerequisites: Introductory course in biochemistry, molecular biology, and genetics and consent of instructor.
Pharmacology 901: Molecular and Cellular Pharmacology Student and Faculty Seminars. Class meets once a week, Mondays at noon. Students and staff present research reports of current interest. All MCP trainees are required to participate in this seminar series that is designed primarily to train the students in the art of effective speaking. Students are required to give a yearly Student Seminar presentation starting in their second year. This course permits trainees to improve their speaking skills, broaden their knowledge in Molecular and Cellular Pharmacology. See MCP Student Handbook for more details.
Pharmacology 990: Rotations. This 3-4 credit course requires three rotations during the fall semester. Work is done under the direction of a faculty member.