- 2010: My current research objectives are focused on elucidating the mechanisms by which the immune system regulates inflammation within the central nervous system (CNS). My research approach utilizes a mouse model of the human autoimmune disease multiple sclerosis, experimental autoimmune encephalomyelitis (EAE), as a means of studying microglial cells and populations of lymphocytes that migrate into the CNS to modulate an inflammatory response. The current goals of my research are to 1) determine the role of B7 expression by microglial cells in regulating CNS inflammation and 2) determine the role of microglial cells in the induction and function of T regulatory cells in the CNS.
- 2007-2008: Post-doctoral Fellowship with Dr. Dittel, Medical College of Wisconsin, Milwaukee, WI
- Conrad AT, and Dittel BN (2011). Taming of macrophage and microglial cell activation by microRNA-124. Cell Res. 21:213-216. PMCID: PMC3193438
- Simonson WT, Markovina S, Grossman WJ, Lokuta MA, Doan AT, Seroogy CM, and Huttenlocher A (2009). Common variable immunodeficiency with regulatory T-cell deficiency treated with rapamycin. Ann Allergy Asthma Immunol. 102:170-171. No abstract available. PMID: 19230472
- Doan AT and Huttenlocher A (2007). RACK1 regulates Src activity and modulates paxillin dynamics during cell migration. Exp Cell Res. 313:2667-2679.PDF PMCID:PMC2679865
- Cox EA, Bennin D, Doan AT, O’Toole T, and Huttenlocher A (2003). RACK1 regulates integrin-mediated adhesion, protrusion, and chemotactic cell migration via its Src-binding site. Mol Biol Cell. 14:658-669. PDF PMCID:PMC149999