My lab is interested in the question of how and why somatic stem cells dysfunction with age. Throughout life, stem cells are responsible for replenishing and regenerating tissue, fundamentally maintaining “youthfulness.” With aging, this ability is lost, resulting in effects such as cognitive impairment, reduced immune response, deterioration of skeletal muscle, and difficulty in wound healing, for example. To develop methods to improve or rescue aging of somatic stem cells, we must understand not only how they age, but also how they remain young.
Recently we have shown that neural stem cells (NSCs) asymmetrically segregate cargoes (e.g. damaged proteins) when they divide, leaving one daughter cell more “clean” than the other. That daughter cell which inherits the damage has a slower proliferation rate than the more “clean” daughter, suggesting that this process may be used for cellular rejuvenation (Moore et al, 2015 Science). This asymmetric segregation is affected with age, suggesting that investigating the mechanisms and cargoes involved in this asymmetric inheritance may reveal a means to improve stem cell aging.
Honors & Awards
- 2017 – Alfred P. Sloan Research Fellow in Neuroscience
- 2016: Society for Neuroscience (SFN) Peter and Patricia Gruber International Research Award
- 2012–2015: Human Frontier Science Program Long-term Postdoctoral Fellowship
- 2014: Keystone NINDS Scholarship Recipient “Adult Neurogenesis” meeting
- 2011–2012: ETH Post-doctoral Fellowship (2 year fellowship/after 1 year exchanged to HFSP)
- 2010: Thermo Fisher Cellome Award 2010 – for the “best published peer-reviewed scientific paper using high-content screening in 2009”
- 2004–2010: Lois Pope LIFE Fellow – The University of Miami Neuroscience Program
- 2008: Medical Faculty Association Travel Award – Margaret Whelan Graduate Student Scholarship Fund
D.L. Moore*, S. Jessberger* (2017). Creating Age Asymmetry: Consequences of Inheriting Damaged Goods in Mammalian Neural Stem Cells. Trends in Cell Biology, 27(1): 82-92. PMID: 27717533*co-corresponding authors
R. Beckervordersandforth, B. Ebert, Schäffner I, J. Moss, C. Fiebig, J. Shin, D.L. Moore, L. Ghosh, M.F. Trinchero, C. Stockburger, K. Friedland, K. Steib, J. von Wittgenstein, S. Keiner, C. Redecker, S.M. Hölter, W. Xiang, W. Wurst, R. Jagasia, A.F. Schinder, G.L. Ming, N. Toni, S. Jessberger, H. Song, D.C. Lie (2017). Role of mitochondrial metabolism in the control of early lineage progression and aging phenotypes in adult hippocampal neurogenesis. Neuron, 93(3): 560-573. PMID: 28111078
- D.L. Moore, G.A. Pilz, M.J. Araúzo-Bravo, Y. Barral, S. Jessberger (2015). A mechanism for the segregation of age in mammalian neural stem cells. Science, 349(6254): 1334-1338.
- D.L. Moore, S. Jessberger. (2013). All astrocytes are not created equal – the role of astroglia in brain injury. EMBO Reports, 14(6): 487-8.
- D.L. Moore, J.L. Goldberg (2011). Multiple transcription factor families regulate axon growth and regeneration. Developmental Neurobiology, 71(12): 1186-211.
- D.L. Moore, A. Apara, and J.L. Goldberg (2011). Kruppel-Like Transcription Factors in the Nervous System: Novel players in neurite outgrowth and axon regeneration. Molecular and Cellular Neuroscience, 47(4): 233-43.
- D.L. Moore and J.L. Goldberg (2010). Four steps to optic nerve regeneration. J Neuro-ophthalmology, 30(4): 347-60.
- M.G. Blackmore, D.L. Moore, R.P. Smith, J.L. Goldberg, J.L. Bixby, and V.P. Lemmon (2010). High content screening of cortical neurons identifies novel regulators of axon growth. Molecular and Cellular Neuroscience, 44(1): 43-54.
- D.L. Moore, M.G. Blackmore, Y. Hu, K.H. Kaestner, J.L. Bixby, V.P. Lemmon, and J.L. Goldberg (2009). KLF Family Members Regulate Intrinsic Axon Regeneration Ability. Science, 326(5950): 298-301.