Faculty: Anjon Audhya, PhD
Associate Professor of Biomolecular Chemistry
|Contact:||5214a Biochemical Sciences|
440 Henry Mall
|Lab Page:||Click Here|
Our laboratory is committed to understanding the fundamental mechanisms by which membrane proteins, lipids, and other macromolecules are transported throughout eukaryotic cells. To do so, we take advantage of numerous interdisciplinary approaches, including biochemistry, structural biology, biophysics, genetics, molecular biology and high-resolution fluorescence and electron microscopy.
Additionally, we use a variety of experimental systems, ranging from simple animal models (e.g. Caenorhabditis elegans) to human induced pluripotent stem cells (iPSCs). We also aim to recapitulate individual steps of membrane transport in vitro, using recombinant proteins and chemically defined lipids. Our ultimate goal is to identify the regulatory pathways that control membrane deformation, which enable vesicle formation in the endosomal and secretory systems. Although basic research is the cornerstone of our program, we also seek to define pathomechanisms that underlie human disease, focusing on the impact of mutations in key trafficking components that lead to cancer, neurodegeneration, asthma, and diabetes. For more information, please visit our lab webpage: www.audhyalab.org.
Honors & Awards
- March of Dimes Basil O'Connor Starter Scholar Award, (2010)
- American Heart Association SDG Award, (2010)
- Shaw Scientist Award (2010)
- DeLill Nasser Award for Professional Development in Genetics (2006)
Selected Publications:(Find further publications on PubMed)
- Mayers JR, Wang L, Pramanik J, Johnson A, Sarkeshik A, Wang Y, Saengsawang W, Yates JR, and Audhya A (2013). Regulation of ubiquitin-dependent cargo sorting by multiple plasma membrane endocytic adaptor proteins.Proc. Natl. Acad. Sci. USA.110:11857-11862.
- Beetz C, Johnson A, Schuh A, Thakur S, Varga R, Fothergill T, Hertel N, Bomba-Warczak E, Thiele H, Nurnberg G, Altmuller J, Saxena R, Chapman ER, Dent EW, Nurnberg P, and Audhya A (2013). Inhibition of TFG function causes hereditary axon degeneration by impairing ER structure. Proc. Natl. Acad. Sci. USA. 110:5091-5096.
- Morrison K, Witte K, Mayers JR, Schuh AL, and Audhya A (2012). Role of acidic phospholipids and nucleotides in regulating membrane binding and activity of a calcium-independent phospholipase A2isoform. J. Biol. Chem. 287:38824-38834.
- Fyfe I, Schuh AL, Edwardson JM, and Audhya A (2011). Association of the endosomal sorting complex ESCRT-II with the Vps20 subunit of ESCRT-III generates a curvature sensitive protein complex capable of nucleating filaments of ESCRT-III.J. Biol. Chem. 286:34262-34270.
- Witte K, Schuh AL, Hegermann J, Sarkeshik A, Mayers JR, Schwarze K, Yates JR, Eimer S, and Audhya A (2011). TFG-1 function in protein secretion and oncogenesis .Nat. Cell Biol.13:550-558.