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Faculty: Emery H. Bresnick, PhD

Director of UW-Madison Blood Research Program

Dept: Professor, Cell & Regenerative Biology
Director, UW Madison Blood Research Program
Contact: 4009 WIMR, L4
1111 Highland Ave
Training Areas:
  • Molecular & Env Toxicology
  • Biostatistics (Affiliate Trainer)
  • Molecular and Cellular Pharmacology
  • Cell & Molecular Biology
  • Biomolecular Chemistry
  • Cancer Biology
  • Biotechnology
  • Pathology & Laboratory Medicine
  • Hematology
  • MD/PhD
  • Translational Cardiovascular Science

Research Interests

Image related to research.

Figure 1

We use multidisciplinary approaches to understand stem/progenitor cell function, normal and malignant blood cell development, and vascular biology. Such approaches include genomics, proteomics, chemical genetics, embryonic stem cell differentiation, computational analysis, and traditional methodologies. In addition to elucidating biological principles, we aim to develop innovative therapeutic strategies based on targeting novel mechanisms.

Mechanisms of hematopoiesis:

We are analyzing the function/regulation of GATA factors that control hematopoietic stem cells (HSCs) and hematopoiesis. Transcriptional profiling and ChIP-seq analysis have identified a cohort of novel GATA factor target genes, including genes encoding proteins that bear no obvious similarity to known proteins. Loss-of-function and gain-of-function studies are being conducted in mice, zebrafish, human adult stem/progenitors, and embryonic stem cell systems to discover new modes of controlling stem/progenitor cell function and to devise novel applications towards translational medicine. Defining novel hematopoietic mechanisms has enormous importance, as deviations from physiological programs yield leukemias, lymphomas, myelodysplasia, and additional blood disorders.

Vascular mechanisms and engineering:

We have developed a novel murine model characterized by severe hematopoietic stem/progenitor cell depletion and a severe vascular integrity defect. We are dissecting mechanisms underlying the establishment and maintenance of vascular integrity in normal and disease states. Understanding such mechanisms is essential for developing efficient approaches to promote the vascularization of engineered tissues, a limiting factor in regenerative medicine.

Go to the Additional Bresnick Website

Honors & Awards

Recent Invited Lectures

Recent Study Section Service

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Selected Publications (Find further publications on PubMed)

  • Gao X, Johnson KD, Chang Y-I, Boyer ME, Dewey C, Zhang J, and Bresnick EH (2013). Gata2 cis-element requirement for hematopoietic stem cell generation in the mammalian embryo. J. Exp. Med. In press
  • Lee HY, Johnson KD, Fujiwara T, Boyer ME, Kim SI, and Bresnick EH (2009). Controlling hematopoiesis through sumoylation-dependent regulation of a GATA factor. Mol Cell. 36:984-95. doi: 10.1016/j.molcel.2009.11.005.
  • Fujiwara T ,O'Geen H, Keles S, Blahnik K, Linnemann AK, Kang YA, Choi K, Farnham PJ, and Bresnick EH (2009). Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy. Mol Cell. 36:667-81. doi: 10.1016/j.molcel.2009.11.001.
  • Zeng X, Sanalkumar R,Bresnick EH, Li H, Chang Q, Keleş S. jMOSAiCS: joint analysis of multiple ChIP-seq datasets. Genome Biol. 2013 Apr 29;14:R38. [Epub ahead of print] PMID: 23844871 [PubMed - as supplied by publisher]
  • Katsumura KR, Devilbiss AW, Pope NJ, Johnson KD, and Bresnick EH (2013).Transcriptional Mechanisms Underlying Hemoglobin Synthesis. Cold Spring Harb Perspect Med. doi:pii: cshperspect.a015412v1. 10.1101/cshperspect.a015412. [Epub ahead of print]PMID: 23838521 [PubMed - as supplied by publisher]
  • Fujita R, Takayama-Tsujimoto M, Satoh H, Gutiérrez L, Aburatani H, Fujii S, Sarai A, Bresnick EH, Yamamoto M, and Motohashi H (2013). NF-E2 p45 Is Important for Establishing Normal Function of Platelets. Mol Cell Biol. 33:2659-70. doi: 10.1128/MCB.01274-12. Epub 2013 May 6. PMID: 23648484 [PubMed - in process]