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Faculty: Shigeki Miyamoto, PhD

Dept: Professor, Oncology
Contact: 6159 WIMR
Training Areas:
  • Molecular and Cellular Pharmacology
  • Cellular & Molecular Biology
  • Molecular Biosciences
  • Cancer Biology
  • MD/PhD Program
  • Hematology Training Program

Research Interests

Our laboratory studies regulation of the transcription factor NF-kB as a model system to learn how normal growth control and cell death are regulated and how deregulation of such processes may contribute to development of cancer. NF-kB is normally sequestered in the cytoplasm by an inhibitor protein, IkB. A variety of extracellular signals induce rapid release of IkB from NF-kB, thereby allowing nuclear translocation of NF-kB to activate target gene expression. The products of these NF-kB target genes regulate diverse biological processes, including immune function, growth control and apoptosis. We are currently investigating the following three specific areas of research:

Honors & Awards

Selected Publications

(Find publications on PubMed)

  • Pak C and Miyamoto S (2013). A New Alpha in Line Between KRAS and NF-κB Activation? Cancer Discov. 3:613-615.
  • Hebron E, Hope C, Kim J, Jensen JL, Flanagan C, Bhatia N, Maroulakou I, Mitsiades C, Miyamoto S, Callander N, Hematti P, and Asimakopoulos F (2013). MAP3K8 kinase regulates myeloma growth by cell-autonomous and non-autonomous mechanisms involving myeloma-associated monocytes/macrophages. Br J Haematol. 160:779-84. Epub 2012 Dec 18. PMID: 23252623
  • McCool KW and Miyamoto S (2012). DNA damage-dependent NF-κB activation: NEMO turns nuclear signaling inside out. Immunol Rev. 246:311-26. Review. PMID: 22435563
  • Young EW, Pak C, Kahl BS, Yang DT, Callander NS, Miyamoto S, and Beebe DJ (2012). Microscale functional cytomics for studying hematologic cancers. Blood. 119:e76-85. Epub 2012 Jan 18. PMID: 22262772
  • Lee MH, Mabb AM, Gill GB, Yeh ET, and Miyamoto S (2011). NF- ∫B induction of the SUMO protease SENP2: A negative feedback loop to attenuate cell survival response to genotoxic stress. Mol Cell. 43:180-91. PMID: 21777808
  • Wuerzberger-Davis SM and Miyamoto S (2010). TAK-ling IKK activation: "Ub" the judge. Sci Signal. 3:pe3. PMID: 20086238
  • McCool K and Miyamoto S (2009). A PAR-SUMOnious mechanism of NEMO activation. Mol Cell. 36:349-50. PMID: 19917242
  • Wuerzberger-Davis SM, Nakamura Y, Seufzer BJ, and Miyamoto S (2006). NF-kB activation by combinations of NEMO SUMOylation and ATM activation stresses in the absence of DNA damage. Oncogene. 26:641-651. PDF PMID 16862178
  • Mabb A, Wuerzberger-Davis SM, and Miyamoto S (2006). PIASy mediates NEMO sumoylation and NF-kB activation in response to genotoxic stress. Nature Cell Biol. 8:986-993. PDF PMID 16906147
  • Chang PY and Miyamoto S (2006). NFKB1 is a direct target of the TAL1 oncoprotein in human T leukemia cells. Cancer Res. 66:6008-6013. PDF PMID 16778171
  • Chang PY and Miyamoto S (2006). Nuclear factor-kappaB dimer exchange promotes a p21(waf1/cip1) superinduction response in human T leukemic cells. Mol Cancer Res. 4:101-112. PDF PMID 16513841
  • Wu Z, Shi Y, Tibbetts RS, and Miyamoto S (2006). Molecular linkage between the kinase ATM and NF-kB signaling in response to genotoxic stimuli. Science 311:1141-1146. PMID 16497931 (Perspective: Bartek J and Lukas J. The stress of finding NEMO. Science. 311:1110-1111.)