Faculty: Vincent Cryns
| Dept: | Professor, Department of Medicine |
|---|---|
| Contact: | 4414 MFCB 1685 Highland Ave Madison, WI (608) 262-4786 vlcryns@medicinewisc.eu |
| Training Areas: | Cellular and Molecular Pharmacology, Medical Science |
| Lab Page: | Click Here |
Research Description
Dr. Cryns leads a multidisciplinary team who focus on understanding how cells die. His group is especially interested in elucidating how abnormalities in cell death contribute to the pathogenesis of cancer and obesity and in translating these insights into improved therapies. Dr. Cryns' research is funded by the NIH, the Breast Cancer Research Foundation, and other agencies. His work has been featured on National Public Radio's "All Things Considered" and highlighted in Nature and Nature Reviews Cancer. Dr. Cryns has been the recipient of several awards, including an Outstanding Junior Faculty Award from the Avon Foundation, and he is an elected member of the American Society for Clinical Investigation.
Dr. Cryns concentrates on five subjects: Apoptosis, Obesity, Biomarkers, Cancer, and Nanotechnolgoy and Therapeutics.
Honors & Awards
- 1991 Nettie Karpin Award, Endocrine Society
- 1993 Young Investigator Award, Amer. Soc. for Bone & Mineral Research
- 1994 Senior Fellows Award, Endocrine Society
- 2003 Outstanding Junior Faculty Award, Avon Foundation
- 2005 Elected member, American Society for Clinical Investigation (ASCI)
- 2006 Drew Senyei, MD Translational Research Award
- 2006-2011 Editorial Board, Molecular Endocrinology
- 2008, 2009 Outstanding Teacher, Feinberg School of Medicine
- 2008-2011 Nominee, Joost Award For Excellence in Teaching, Feinberg School of Medicine
- 2009 Editorial Board, Journal of Signal Transduction
- 2010 Editorial Board, Journal of Stem Cell Research and Therapy, Journal of Drug Metabolism and Toxicology
- 2010 Associate Editor-in-Chief, American Journal of Cancer Research
- 2011 Nominee, Faculty Mentor of the Year, Feinberg School of Medicine
- 2011 Chair, Nanotechnology Session, American Association for Cancer Research (AACR) 2011 Annual Meeting
- 2011 Co-chair, Animal Models Working Group, NCI Alliance for Nanotechnology in Cancer
- 2012 Chair, Clinical Endocrinology Subcommittee, Endocrinology Section, 2012 American Association for Cancer Research (AACR) Program Committee
Selected Publications
- Goldberg MS, Hook SS, Wang AZ, Bulte JW, Patri AK, Uckun FM,Cryns VL, Hanes J, Akin D, Hall JB, Gharkholo N, Mumper RJ. Biotargeted nanomedicines for cancer: six tenets before you begin. Nanomedicine (Lond). 2013 Feb;8(2):299-308. doi: 10.2217/nnm.13.3.PMID: 23394158
- Toft DJ, Moyer TJ, Standley SM, Ruff Y, Ugolkov A, Stupp SI,Cryns VL. Coassembled cytotoxic and pegylated peptide amphiphiles form filamentous nanostructures with potent antitumor activity in models of breast cancer. ACS Nano. 2012 Sep 25;6(9):7956-65. Epub 2012 Aug 28.PMID: 22928955
- Soukasene S, Toft DJ, Moyer TJ, Lu H, Lee HK, Standley SM,Cryns VL, Stupp SI. Antitumor activity of peptide amphiphile nanofiber-encapsulated camptothecin. ACS Nano. 2011 Nov 22;5(11):9113-21. doi: 10.1021/nn203343z. Epub 2011 Nov 1. PMID: 22044255
- Antin JH, Aplin AE, Cheng SY, Emmert-Buck MR,Cryns VL, Wang D. American journal of cancer research: editorial board (2011). Am J Cancer Res. 2011;1(6):817-22. Epub 2011 Jun 28. No abstract available.PMID: 22016829
- Antin JH, Emmert-Buck MR, Aplin AE, Cheng SY,Cryns VL, Wang D. Launching of American Journal of Cancer Research. Am J Cancer Res. 2011;1(1):i. Epub 2010 Nov 5. No abstract available.PMID: 21969259
- Su J, Chen F,Cryns VL, Messersmith PB. Catechol polymers for pH-responsive, targeted drug delivery to cancer cells. J Am Chem Soc. 2011 Aug 10;133(31):11850-3. doi: 10.1021/ja203077x. Epub 2011 Jul 19.PMID: 21751810
- Malin D, Chen F, Schiller C, Koblinski J,Cryns VL. Enhanced metastasis suppression by targeting TRAIL receptor 2 in a murine model of triple-negative breast cancer. Clin Cancer Res. 2011 Aug 1;17(15):5005-15. doi: 10.1158/1078-0432.CCR-11-0099. Epub 2011 Jun 8. PMID: 21653692
- Toft DJ,Cryns VL. Minireview: Basal-like breast cancer: from molecular profiles to targeted therapies. Mol Endocrinol. 2011 Feb;25(2):199-211. doi: 10.1210/me.2010-0164. Epub 2010 Sep 22. Review. PMID: 20861225