Faculty: Beth A. Weaver, PhD
|Dept:||Assistant Professor, Cell & Regenerative Biology|
|Contact:|| 6109 WIMR,
1111 Highland Ave
- Chromosome segregation during mitosis
- Effects of chromosome missegregation on tumors
Future research in the lab will focus on:
- Genes required for accurate chromosome segregation;
- The types of chromosome segregation errors that drive tumor promotion versus tumor suppression; and
- The context-dependent factors that influence the effects of aneuploidy on normal cells and on tumors.
Honors & Awards
- 2006-2008 Postdoctoral Fellowship, Philip Morris Foundation
- 2006 Brigid G. Leventhal Scholar in Cancer Research Award
- Choudhary A, Lera RF, Martowicz ML, Oxendine K, Laffin JJ, Weaver BA, and Burkard ME (2013). Interphase cytofission maintains genomic integrity of human cells after failed cytokinesis. Proc Natl Acad Sci U S A. 2013 Jul 22. [Epub ahead of print]
- Zasadil LM, Britigan EM, and Weaver BA (2013). 2n or not 2n: Aneuploidy, polyploidy and chromosomal instability in primary and tumor cells. Semin Cell Dev Biol. 24:370-379. PMID: 23416057
- Harkness T, Weaver BA, Alexander CM, and Ogle BM (2013). Cell fusion in tumor development: accelerated genetic evolution. Crit Rev Oncog. 18(1-2):19-42. PMID: 23237551
- Ryan SD, Britigan EMC, Zasadil LM, Witte K, Audhya A, Roopra A, and Weaver BA (2012). Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisons. Proc Natl Acad Sci USA. 109:e2205-2214
- Weaver BA and Cleveland DW (2009). The role of aneuploidy in promoting and suppressing tumors. J Cell Biol. 185:935-937. PMID: 19528293
- Weaver BA, Cleveland DW (2008). The aneuploidy paradox in cell growth and tumorigenesis. Cancer Cell. 14:431-433. PMID: 19061834
- Weaver BA and Cleveland DW (2007). Aneuploidy: instigator and inhibitor of tumorigenesis. Cancer Res. 67:10103-10105.
- Weaver BA and Cleveland DW (2007). Comment on A centrosome-independent role for gamma-TuRC proteins in the spindle assembly checkpoint. Science. 18:982.
- Weaver BA, Silk AD, Montagna C, Verdier-Pinard P, and Cleveland DW (2007). Aneuploidy acts both oncogenically and as a tumor suppressor. Cancer Cell. 11:25-36.
- Weaver BA and Cleveland DW (2006). Does aneuploidy cause cancer? Curr Opin Cell Biol. 18:658-67.
- Weaver BA, Silk AD, and Cleveland DW (2006. Nondisjunction, aneuploidy and tetraploidy. Nature. 442:9-10.
- Weaver BA and Cleveland DW (2005) Decoding the links between mitosis, cancer, and chemotherapy: The mitotic checkpoint, adaptation, and cell death. Cancer Cell. 8:7-12.
- Kops GJPL, Weaver BA, and Cleveland DW (2005). On the road to cancer: aneuploidy and the mitotic checkpoint. Nat Rev Cancer. 5:773-785.
- Kops GJPL, Kim Y, Weaver BA, Mao Y, McLeod I, Yates JR, Tagaya M, and Cleveland DW (2005). ZW10 links mitotic checkpoint signaling to the structural kinetochore. J Cell Biol. 169:49-60.
- Weaver BA, Bonday ZQ, Putkey FR, Kops GJPL, Silk AD, and Cleveland DW (2003). Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss. J Cell Biol. 162:551-63.