Faculty: Beth A. Weaver
|Dept:||Assistant Professor, Cell & Regenerative Biology|
|Contact:|| 6109 WIMR
Molecular & Cellular Pharmacology
- Chromosome segregation during mitosis
- Effects of chromosome missegregation on tumors
Future research in the lab will focus on:
- Genes required for accurate chromosome segregation;
- The types of chromosome segregation errors that drive tumor promotion versus tumor suppression; and
- The context-dependent factors that influence the effects of aneuploidy on normal cells and on tumors.
Honors & Awards
- 2006-2008 Postdoctoral Fellowship, Philip Morris Foundation
- 2006 Brigid G. Leventhal Scholar in Cancer Research Award
- 1999-2002 National Cancer Institute Training Grant Recipient
- 1999 Teaching Assistant, University of California, San Diego
- Zasadil LM, Britigan EM, Weaver BA. 2n or not 2n: Aneuploidy, polyploidy and chromosomal instability in primary and tumor cells. Semin Cell Dev Biol. 2013 Feb 13. doi:pii: S1084-9521(13)000190-0. 10.1016/j.semcdb.2013.02.001. PMID: 23416057
- Harkness T, Weaver BA, Alexander CM, Ogle BM. Cell fusion in tumor development: accelerated genetic evolution. Crit Rev Oncog. 2013;18(1-2):19-42. PMID: 23237551
- Ryan, SD, Britigan, EMC, Zasadil LM, Witte K, Audhya A, Roopra A. and Weaver, BA. (2012) Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisons. Proc Natl Acad Sci USA, July 9.
- Weaver BA, Cleveland DW (2009). The role of aneuploidy in promoting and suppressing tumors. J Cell Biol. 185:935-937. PMID: 19528293
- Weaver BA, Cleveland DW (2008). The aneuploidy paradox in cell growth and tumorigenesis. Cancer Cell. 14(6):431-433. PMID: 19061834
- Weaver BAA and Cleveland DW. (2007). Aneuploidy: instigator and inhibitor of tumorigenesis. Cancer Res. 67:10103-10105.
- Weaver BAA and Cleveland DW. (2007). Comment on A centrosome-independent role for gamma-TuRC proteins in the spindle assembly checkpoint. Science. 18:982.
- Weaver BAA, Silk AD, Montagna C, Verdier-Pinard P, and Cleveland DW. (2007). Aneuploidy acts both oncogenically and as a tumor suppressor. Cancer Cell. 11:25-36.
- Weaver BAA and Cleveland DW. (2006). Does aneuploidy cause cancer? Curr Opin Cell Biol. 18:658-67.
- Weaver BAA, Silk AD, and Cleveland DW. (2006. Nondisjunction, aneuploidy and tetraploidy. Nature. 442:9-10.
- Weaver BAA and Cleveland DW. (2005) Decoding the links between mitosis, cancer, and chemotherapy: The mitotic checkpoint, adaptation, and cell death. Cancer Cell. 8:7-12.
- Kops GJPL, Weaver BAA, and Cleveland DW. (2005. On the road to cancer: aneuploidy and the mitotic checkpoint. Nat Rev Cancer. 5:773-785.
- Kops GJPL, Kim Y, Weaver BA, Mao Y, McLeod I, Yates JR, Tagaya M, and Cleveland DW. (2005). ZW10 links mitotic checkpoint signaling to the structural kinetochore. J Cell Biol. 169:49-60.
- Weaver BA, Bonday ZQ, Putkey FR, Kops GJPL, Silk AD, and Cleveland DW. (2003). Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss. J Cell Biol. 162:551-63.