Faculty: Yongna Xing, PhD
|Dept:||Assistant Professor, Oncology|
|Contact:|| 421A McArdle
|Lab Page:||Click Here|
My lab is interested in elucidation of signaling pathways related to cancer using multi-disciplinary biophysics and biochemical approaches, including structural biology and proteomics, in combination with cell biology. We focus on signaling pathways that affect cancer cell metabolism and cancer cell genome integrity.
Protein phosphatase 2A (PP2A) is involved in many essential cellular functions. Deregulation of PP2A function is frequently linked to multiple types of cancer. The importance of PP2A function also resides in its crosstalk with the Tor signaling pathway, which has broad effects on cell growth and metabolism. PP2A also interacts with PML, a major component of PML-nuclear body (PML-NB) that is missing in later stage of tumors. PML is considered an important tumor suppressor and has important functions in genome integrity and as an antiviral. Structural biology in combination with biochemistry and proteomics will provide powerful tools for elucidation of the structure and function of the key components in the regulation of PP2A, Tor and PML, as well as the crosstalk among them. Results from these aspects of our research will have a direct impact on the design of therapeutics against cancer.
- Jiang L, Stanevich V, Satyshur KA, Kong M, Watkins GR, Wadzinski BE, Sengupta R, and Xing Y (2013). Structural basis of protein phosphatase 2A stable latency. Nat Commun. 4:1699. PMID 23591866
- Mezrich JD, Nguyen LP, Kennedy G, Nukaya M, Fecnher JH, Zhang X, Xing Y, and Bradfield CA (2012). SU5416, a VEGF receptor inhibitor and ligand of the AHR, represents a new alternative for immunomodulation. PLoS One. 7:e44547. Epub 2012 Sep 6. PMID: 22970246
- Xing Y, Nukaya M, Satyshur KA, Jiang L, Stanevich V, Krokmaz EN, Burdette L, Kennedy GD, Cui Q, and Bradfield CA (2012). Identification of the Ah-receptor structural determinants for ligand preferences. Toxicol Sci. 129:86-97. Epub 2012 Jun 2. PMID: 22659362
- Stanevich V, Jiang L, Satyshur KA, Li Y, Jeffrey PD, Li Z, Menden P, Semmelhack MF, and Xing Y (2011). The structural basis for tight control of PP2A methylation and function by LCMT-1. Mol Cell. 41:331-42. PMID: 21292165
- Dickerson SJ, Xing Y, Robinson AR, Seaman WT, Gruffat H, and Kenney SC.(2009). Methylation-Dependent Binding of the Epstein-Barr Virus BZLF1 Protein to Viral Promoters. PLoS Pathog. 5:e1000356.
- Xing Y, Li Z, Chen Y, Stock JB, Jeffrey PD, and Shi . (2008). Structural Mechanism of Demethylation and Inactivation of Protein Phosphatase 2A. Cell. 133:154-163.