Dr. Kwon’s lab actively pursues pharmaceutical research in nanomedicine that focuses on polymeric assemblies for drug delivery, non-viral gene delivery and optical imaging. Within this context, they are very interested in fundamental pharmaceutical concepts in drug solubilization, controlled release and drug targeting. These insights into polymeric assemblies allow us to explore therapeutic strategies that involve novel nanomedicines that are bio-responsive, synergistic and theranostic, aiming for progress against lung, breast and ovarian cancers and also systemic fungal diseases.
- H. Cho and G. S. Kwon, “Thermosensitive poly(d,l-lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(d,l-lactide-co-glycolide) hydrogels for multi-drug delivery,” J. Drug Targeting, 22, 669-677 (2014).
- T. C. Lai, H. Cho and G. S. Kwon, “Reversibly core cross-linked polymeric micelles with pH- and reduction-sensitivites: effects of cross-linking degree on particle stability, drug release kinetics, and anti-tumor efficacy,” Polym. Chem., 5, 1650-1661 (2014).
- H. Cho, C. S. Cho, G. L. Indig, A. Lavansanifar, M. R. Vakili, and G. S. Kwon, “Polymeric micelles for apoptosis-targeted optical imaging of cancer and intraoperative surgical guidance,” PLoS One, 9, e89968 (2014).
- T. Yoshida, T. C. Lai, G. S. Kwon, and K. Sako, “pH- and ion-sensitive polymers for drug delivery,” Expert Opin. Drug Deliv., 10, 1497-1513 (2013).
- H. Cho, T. C. Lai, and G. S. Kwon, “Poly(ethylene glycol)-block-poly(epsilon-caprolactone) micelles for combination drug delivery: evaluation of paclitaxel, cyclopamine, and gossypol in intraperitoneal xenograft models of ovarian cancer,”J. Controlled Release, 166, 1-9 (2013).