Persistent agonizing pain long after the wound has healed is a clinical problem with no good treatment. We investigate the basic signaling pathways thought to mediate the transformation from acute injury to persistent pain. Various signaling molecules under investigation include the HCN and TTX-resistant ion channels responsible for the generation of spontaneous action potentials in the sensory nerve, MEK1, MMP, and Sigma1R as intracellular signaling molecules mediating pathological pain. Our long-range plan is to use the knowledge gained to come up with a gene-therapy approach using recombinant lentivirus or adeno-associated virus to treat pathological pain.
- Tyler Duellman. Research Assistant, firstname.lastname@example.org
- Jack Burnett, Research Specialist, email@example.com
Honors & Awards
- 2013 Elected Member, Academy of Research Mentors, Foundation for Anesthesia Research and Education, Rochester, MN
- 2009 Betty Bamforth Endowed Chair in Anesthesiology Research, University of Wisconsin, Madison WI
- 1996 Elected Member, Association of University Anesthesiologists, Seattle WA
Selected Publications (Find further publications on PubMed)
- Duellman T, Warren CL, Peissig P, Wynn M, and Yang J (2012). “Matrix metalloproteinase-9 genotype as a potential genetic marker for abdominal aortic aneurysm.” Circ Cardiovasc Genet. 5:529-537. Epub 2012 Aug 31. PMID: 22942228
- Duellman T, Warren C, and Yang J (2014). “Single nucleotide polymorphism-specific regulation of matrix metalloproteinase-9 by multiple miRNAs targeting the coding exon”, Nucleic Acid Research, 42:5518-5531. PMCID: PMC4027190
- Duellman T, Warren CL, Matsumura J, Yang J (2014) “Case-control logistic regression analysis of multiple genetic polymorphisms in aggressive- and slow-growing abdominal aortic aneurysms”, J Vasc Surgery,60: 613-621, 2014. PMID 24801553. PMCID: PMC4176942.
- Chu UB, Duellman T, Weaver SJ, Yang J (2015) “Endothelial protection by statin is mimicked by FTI-277 and GGTI-298 drug combination -mediated ERK5 activation”, Biochem Biophys Acta, 1850: 1415-1425. PMID 25829196; PMCID: PMC4465438.
- Kim HT, Uchimoto K, Duellman T, Yang J (2015) “Automated assessment of pain in rats using a voluntarily accessed static weight-bearing test”, Physiol Behav, [EPub July 2 2015]. PMID: 26143745