Judith Kimble, PhD

Dept: Vilas Professor, Biochemistry Investigator, Howard Hughes Medical Institute
Contact: 341E Biochemistry Addition
433 Babcock Drive
(608) 262-6188
jekimble (at) wisc (dot) edu
Training Areas:
  • Molecular and Cellular Pharmacology
  • Biochemistry
  • Genetics
  • Cellular and Molecular Biology
  • Cell and Regenerative Biology
  • Medical Sciences
Web Page: Click Here

Research Description

Our lab focuses on germline stem cells (GSCs) and their regulation in the nematode C. elegans. GSCs rimageforkimble_000eside within a stem cell niche and generate daughter cells that differentiate (see figure). This niche uses Notch signaling to maintain GSCs. Notch signaling in turn activates a regulatory network to maintain germ cells in a stem cell state or to drive them into differentiation. FBF, a conserved sequence-specific RNA binding protein, provides the major hub for maintenance of adult stem cells. FBF functions as a broad-spectrum regulator of differentiation with many target mRNAs shared with its human PUF counterparts. We continue to analyze regulators of stem cell maintenance, regulators of differentiation as sperm or oocyte and the molecular network that encompasses both stem maintenance and differentiation.

Honors & Awards

  • President, Society for Developmental Biology, 2004-2005
  • Hilldale Award, Biological Sciences Division, 2003
  • American Philosophical Society, 2002
  • Vilas Professorship, 2001
  • National Academy of Sciences, 1elected in 1995

Selected Publications

(Find further recent publications on PubMed)