Monica Gavala, PhD

Graduation: 08/2008
Advisor: Bertics, Paul
Current Position: Senior Associate Scientist
Amgen
San Francisco, CA
Research Interest: Role of the P2RX7 nucleotide receptor in transcriptional activation of monocytic cells
Email: mlgavala (at) wisc (dot) edu

Alumni News

  • Summer 2013: started new job at Amgen in Seattle, Washington
  • 9/2012-8/2013: Dr. Gavala worked with Dr. Loren Denlinger who specializes in Allergies specifically P2X7 (Dept of Medicine, UW-Madison)
    • Provided guidance for graduate students and technicians on various aspects of aforementioned grants
    • Collaborated with other laboratories on campus on research projects. Examples:
    • Effect of nucleotide receptor activation on the release of cytokines from bacterially (LPS)-challenged monocytic cells
    • Intracellular signaling pathways induced after human rhinovirus (HRV) infection of primary peripheral blood monocytes and alveolar macrophages
    • Mediators released in the lungs after in vivo allergen challenge in mild asthmatics (analysis of bronchial alveolar lavage fluid)
    • Effect of interleukin-5 depletion on the responsiveness of airway and peripheral blood eosinophils to stimuli

Specializations

  • Signal Transduction, Immunology, Clinical Research, Cell Culture, Biochemistry, Flow Cytometry, Western Blotting, Immunoassays, qPCR, Program Management, Laboratory Experience, Fluorescence, Transfection, Virology, Microbiology, asthma, Grant Writing, Computer Literate, Cell Signaling, Microscopy, Genetics, Confocal Microscopy, and Fluorescence Microscopy, Assay Development, Asthma, RNA isolation

Publications

  • Gavala ML, Kelly EA, Esnault S, Kukreja S, Evans MD, Bertics PJ, Chupp GL, and Jarjour NN (2013). Segmental allergen challenge enhances chitinase activity and levels of CCL18 in mild atopic asthma. Clin Exp Allergy. 43:187-197. PMCID: PMC3623278
  • Gavala ML, Bashir H, and Gern JE (2013). Virus/Allergen interactions in asthma. Cuur Allergy Asthma Rep. 13: 298-307. PMID: 23475539
  • Gavala ML, Bertics PJ, and Gern JE (2011). Rhinoviruses, allergic inflammation, and asthma. Immunol Rev. 242:69-90. Review. PMCID:PMC3119863
  • Lenertz LY, Gavala ML, Zhy Y, and Bertics PJ (2011). Transcriptional control mechanisms associated with the nucleotide receptor P2X7, a critical regulator of immunologic, osteogenic, and neurologic functions. Immunol Res. 50:22-38. Review. PMCID:PMC3203638
  • Gavala ML, HIll LM, Lenertz LY, Karta MR, and Bertics PJ (2010). Activation of the the transcription factor FosB/activating protein-1 (AP-1) is a prominent downstream signal of the extracellular nucleotide receptor P2RX7 in monocytic and osteoblastic cells. J Biol Chem. 285:34288-34298. Epub 2012 Sep 2. PMCID:PMC296527
  • Hill LM, Gavala ML, Lenertz LY, and Bertics PJ (2010). Extracellular ATP may contribute to tissue repair by rapidly stimulating purinergic receptor X7-dependent vascular endothelial growth factor release from primary human monocytes. J Immunol. 185:3028-34. Epub 2012 Jul 28. PMCID:PMC3156583
  • Lenertz LY, Wang Z, Guadarrama A, Hill LM, Gavala ML, and Bertics PJ (2010.)Mutation of Putative N-linked Glycosylation Sites on the Human Nucleotide Receptor P2X7 Reveals a Key Residue Important for Receptor Function.Biochemistry. 48:4611-4619. PMCID:PMC289574
  • Lenertz LY, Gavala ML, Hill LM, and Bertics PJ (2009). Cell signaling via the P2X(7) nucleotide receptor: linkage to ROS production, gene transcription, and receptor trafficking. Purinergic Signal. 5:175-187. PMCID:PMC2686823
  • Gavala ML, Pfeiffer ZA, and Bertics PJ (2008). The nucleotide receptor P2RX7 mediates ATP-induced CREB activation in human and murine monocytic cells. J Leukoc Biol. 84:1159-1171. PMCID:PMC2538603