Nader Sheibani, PhD

nader_sheibani
Dept: Professor, Ophthalmology and Visual Sciences
Contact: Wisconsin Institute for Medical Research
1111 Highland Ave, Room 9418
(608) 263-3345
nsheibanikar (at) wisc (dot) edu
Training Areas:
  • Molecular and Cellular Pharmacology Program
  • Cellular & Molecular Pathology Program
  • Cellular & Molecular Biology Program

 

Research Interests

Our laboratory studies the molecular and cellular mechanisms that regulate angiogenesis. We are interested in how alterations in normal regulatory mechanisms, under pathological conditions such as ischemia and diabetes, leads to vascular abnormalities and neovascularization. We use the postnatal developing retinal vasculature as a model to study all aspects of vascular development. In addition, we have established a number of mouse models to study neovascularization associated with aging, ischemia and diabetes. Our in vivo studies are complemented with our unique ability to culture retinal vascular cells from wild type and transgenic mice for in vitro studies. The utilization of these models has provided novel insight into the role of a number of genes in regulation of retinal vascular development and neovascularization. We are also utilizing our vascular cells for development of cell-based assays for identification of small molecules with potential therapeutic benefit for various eye diseases with a neovascular component.

Honors & Awards

  • 1980 Freshman Chemistry Achievement Award, Nasson College
  • 1980 George Nasson Scholar, Nasson College
  • 1982 Presidential Scholarship, Nasson College
  • 1982 Mathematics and Science Achievement Award, Nasson College
  • 1982 Graduated Magna Cum Laude, Nasson College
  • 1982 George Nasson Scholar, Nasson College
  • 1984 Summer Research Fellowship, University of New Hampshire
  • 1987 Finalist, Dorsey Award for Excellence in Manuscript Writing, Univ of Nebraska Medical Center
  • 1988 Presidential Graduate Fellow, University of Nebraska Medical Center
  • 2000 Atorvastatin Research Award
  • 2002 Career Development Award, Research to Prevent Blindness
  • 2005 Juvenile Diabetes Research Foundation Innovative Research Award
  • 2010 NIH Director Research Award

Selected Publications:

  • Park S, Sorenson CM, Sheibani N. (2015), “PECAM-1 isoforms, eNOS and endoglin axis in regulation of angiogenesis.,” Clin Sci (Lond). 2015 Aug 1;129(3):217-34. doi: 10.1042/CS20140714. PMID: 25976664
  • Farnoodian M, Kinter JB, Yadranji Aghdam S, Zaitoun I, Sorenson CM, Sheibani N. (2015), “Expression of pigment epithelium-derived factor and thrombospondin-1 regulate proliferation and migration of retinal pigment epithelial cells.,” Physiol Rep. 2015 Jan 19;3(1). pii: e12266. doi: 10.14814/phy2.12266. Print 2015 Jan 1. PMID: 25602019
  • Fei P, Zaitoun I, Farnoodian M, Fisk DL, Wang S, Sorenson CM, Sheibani N. (2014), “Expression of thrombospondin-1 modulates the angioinflammatory phenotype of choroidal endothelial cells.,” PLoS One. 2014 Dec 30;9(12):e116423. doi: 10.1371/journal.pone.0116423. eCollection 2014. PMID: 25548916
  • Gurel Z, Zaro BW, Pratt MR, Sheibani N.(2014) “Identification of O-GlcNAc Modification Targets in Mouse Retinal Pericytes: Implication of p53 in Pathogenesis of Diabetic Retinopathy,” PLoS One. 2014 May 1;9(5):e95561. doi: 10.1371/journal.pone.0095561. eCollection 2014. PMID: 24788674
  • Shin ES, Huang Q, Gurel Z, Palenski TL, Zaitoun I, Sorenson CM, Sheibani N. (2014) “STAT1-mediated Bim expression promotes the apoptosis of retinal pericytes under high glucose conditions,” Cell Death Dis. 2014 Jan 9;5:e986. doi: 10.1038/cddis.2013.517. PMID: 24407239