The amino acid sequence of a protein encodes its three-dimensional structure, and this structure manifests itself in biological function. Using techniques that range from synthetic chemistry to biochemistry to cell biology, the Raines group is illuminating in atomic detail both the chemical basis and the biological purpose for protein structure and protein function. The efforts of the Raines group are leading to insights into the relationship between amino acid sequence and protein function (or dysfunction), as well as to the creation of novel molecules with desirable properties. The research projects in the Raines laboratory are designed to reveal how biological phenomena can be explained with the principles of chemistry. The hypotheses are far-reaching, and testing them requires the use of techniques and ideas from diverse disciplines. This broad/deep training is appropriate for scientists who want to perform innovative and meaningful research at the widening chemistry – biology interface.
Honors & Awards
- 2013 – Jeremy Knowles Award, Royal Society of Chemistry
- 2010 – Repligen Award, American Chemical Society
- 2005 – Emil Thomas Kaiser Award, Protein Society
- 2004 – Arthur C. Cope Scholar Award, American Chemical Society
- 1998 – Pfizer Award, American Chemical Society
- Chattopadhyay S, Guthrie KM, Teixeira L, Murphy CJ, Dubielzig RR, McAnulty JF,Raines RT. (2015) Anchoring a cytoactive factor in a wound bed promotes healing. J Tissue Eng Regen Med. PMID: 24677775, in press [EPub ahead of print 2014]
- Eller CH, Chao T-Y, Singarapu KK, Ouerfelli O, Yang G, Markley JL, Danishefsky SJ, Raines RT (2015) Human cancer antigen Globo H is a cell-surface ligand for human ribonuclease 1. ACS Central Sci, In Press.
- Andersen KA, Aronoff MR, McGrath NA, Raines RT (2015) Diazo groups endure metabolism and enable chemoselectivity in cellulo. J Am Chem Soc 137:2412–2415.
- Johnston, SB, Raines RT (2015) Conformational stability and catalytic activity of PTEN variants linked to cancers and autism spectrum disorders. Biochemistry 54:1576–1582.
- Desai KK, Cheng CL, Bingman CA, Phillips GN Jr, Raines RT (2014) A tRNA splicing operon: Archease endows RtcB with dual GTP/ATP cofactor specificity and accelerates RNA ligation. Nucleic Acids Res 42:3931–3942.