Cell Biology of neuronal trafficking in physiology and neurodegenerative diseases. The Roy lab is interested in the cell biology of neuronal trafficking in physiology and disease. A general approach in the lab is to develop simple cellular models of normal and abnormal biological phenotypes – using dissociated neurons, 3-D organoids, and induced pluripotent stem cells (iPSC’s) – and test predictions from these models in brains. Current projects include novel uses of CRISPR-Cas9 technology in cellular model-systems of neurodegenerative diseases, optogenetic approaches to study slow axonal transport, and use of iPSC’s to explore human cell biology. The lab has ongoing collaborations with researchers at the Wisconsin Institute for Discovery (WID), the Waisman Center, and other investigators at UW-Madison; and is located on modern, state of the art laboratory and office space overlooking lake Mendota (within the Wisconsin Institute for Medical Research or WIMR-II tower: WIMR-II-science-without-walls).
Honors & Awards:
2016 UW Medical Foundation Professorship
2011 American Federation of Aging Research
2011 John S. Spice Award in aging from the Larry Hillblom Foundation
“α-synuclein multimers cluster synaptic vesicles and attenuate recycling.” Curr. Biol.. 2014;24(19):2319-26.
“Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway.” Neuron. 2013;79(3):447-60.
“A dynamic formin-dependent deep F-actin network in axons.” Journal of Cell Biology. 2015;210(3):401-417.
“Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway.” Nat. Neurosci.. 2016;19(1):55-64.
“A dynamic formin-dependent deep F-actin network in axons.” J. Cell Biol.. 2015;210(3):401-17.