My overall research interest is to determine how skeletal muscles sense mechanical information and convert this stimulus into the molecular events that regulate changes in muscle mass. This interest has led me to study a protein kinase called the mammalian target of rapamycin (mTOR). Signaling by mTOR is necessary for mechanically-induced growth of skeletal muscle, and I have recently determined that mechanical stimuli activate mTOR signaling through a unique mechanism involving phospholipase D and the lipid second messenger phosphatidic acid (PLD!íPA!ímTOR). Based on this observation, my lab has focused on three projects which are all aimed at further defining how mechanical stimuli activate the PLD!íPA!ímTOR pathway and skeletal muscle growth.
Honors & Awards
- Vilas Associate Award
- Ruth L. Kirschstein National Research Service Award
- American Federation of Aging Research, Glenn Scholar
- You JS, Anderson GB, Dooley MS, and Hornberger TA. The Role of mTOR Signaling in the Regulation of Protein Synthesis and Muscle Mass During Immobilization. Dis. Model. Mech. 2015 Jun 18. [Epub ahead of print] PMCID – PMC Journal In Process
- Goodman CA, Deitz JM, You JS, Jacobs BL, McNally RM and Hornberger TA. Yes-associated protein is up regulated by mechanical overload and is sufficient to induce skeletal muscle hypertrophy. FEBS Letters, May 8. [Epub ahead of print] PMCID – PMC Journal In Process
- White JP, Wrann, CD, Rao RR, Nair SK, Jedrychowski MP, You JS, Gygi SP, Ruas JL, Hornberger TA, Wu Z, Glass DJ, Piao X and Spiegelman BM. G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy. Proc Natl Acad. Sci USA. 2014 Nov 4;111(44):15756-61. PMCID – PMC4226111
- Frey JW, Jacobs BL, Goodman CA, and Hornberger TA (2014). A role for Raptor phosphorylation in the mechanical activation of mTOR signaling. Cell Signal. Feb;26:313-22. Epub 2013 Nov 13.
- You JS, Lincoln HC, Kim CR, Frey JW, Goodman CA, Zhong XP, Hornberger TA (2014). The role of diacylglycerol kinase ζ and phosphatidic acid in the mechanical activation of mammalian target of rapamycin (mTOR) signaling and skeletal muscle hypertrophy.J Biol Chem. 2014 Jan 17;289:1551-63. Epub 2013 Dec 3.