Yiming Zhu, PhD

Graduation: 06/2010
Advisor: Bertics, Paul
Current Position: Scientist II
Five Prime Therapeutics, Inc.
South San Francisco, CA
Research Interest: Human immunology and hematology, allergic and inflammatory disease, human primary cells, lysosomal biology and autophagy
Email: yimingzhu (at) hotmail (dot) com

Alumni News

  • Former Position: Post-doctoral fellowship, R&D Department
    BioMarin Pharmaceutical Inc., Novato, CA
    Research Interest: Concentrating in Human Immunology and Inflammation.

Highlights of Qualifications

  • Human Immunology and Hematology, Allergic and Inflammatory Disease, Human Primary cells, Lysosomal Biology and Autophagy
  • Extensive knowledge in human immunology and hematology
  • Experienced with allergic and inflammatory diseases (allergy, asthma, rheumatoid arthritis, osteoporosis)
  • Experienced with human primary cells (eosinophils, macrophages, osteoclasts, osteoblasts and chondrocytes)
  • Knowledge of lysosomal biology and autophagy

Key Laboratory Skills

Flow cytometry, Automacs cell-sorting, Immunocytochemistry, Primary cell cultures and differentiation, qPCR/RT-PCR, siRNA, Western Blot, Immunoprecipitation, human blood processing, Cells-based assays: ELISA/ MSD assay, migration, adhesion, degranulation, ROS detection

Specialties

  • Chronic inflammatory diseases
  • Human primary hematopoietic cells
  • Human blood processing
  • Cell-based immunology assays

Publications

  • Yeh FL, Zhu Y, Tepp WH, Johnson EA, Bertics PJ, and Chapman ER. (2011) Retargeted clostridial neuro-toxins as novel agents for treating chronic diseases.Biochemistry. 50:10419-10421. PMCID: PMC3226321
  • Lenertz LY, Gavala ML, Zhu Y, and Bertics PJ. (2011) Transcriptional control mechanisms associated with the nucleotide receptor P2X7, a critical regulator of immunologic, osteogenic, and neurologic functions. Immunol Res. 2011 Feb 6. [Epub ahead of print]  PMID: 21298493
  • Zhu Y, and Bertics PJ. (2011) Chemoattractant-induced signaling via the Ras-ERK and PI3K-Akt networks, along with leukotriene C4 release, is dependent on the tyrosine kinase Lyn in IL-5- and IL-3-primed human blood eosinophils. J Immunol. 186:516-526. Epub 2010 Nov 24. PMID: 21106848
  • Bates ME, Sedgwick JB, Zhu Y, Liu LY, Heuser RG, Jarjour NN, Kita H, Bertics PJ.  (2010) Human airway eosinophils respond to chemoattractants with greater eosinophil-derived neurotoxin release, adherence to fibronectin, and activation of the Ras-ERK pathway when compared with blood eosinophils. J Immunol.184:7125-7133. Epub 2010 May 21. PMID: 20495064