- Past Experience:Before transferring to Bastyr University California, Dr. Cho was a core faculty member in the Department of Basic Sciences at Bastyr University’s Kenmore campus, where he taught a variety of undergraduate and graduate courses for students of naturopathic medicine, acupuncture and Oriental medicine, herbal sciences and nutrition.Dr. Cho has conducted postdoctoral research as a team leader of endocrine drug discovery and physiologic impacts of the nuclear bile acid receptor on immune response. He has taught cell biology and human physiology at California State University.Dr. Cho also has served as an advisor for student research. His research is focused on anti-adipogenic effects of natural bile acids as well as anti-tumorigenic effects of Chinese herbal extracts.
- Classes Taught:Pharmacology, Pharmacology of Cancer, Pathology of Cancer, Biochemistry, Organic Chemistry and Disease Processes.
- Interests:Dr. Cho’s research topics include physiological effects of bile acids on fibroblastic transformation into fat cells. He has screened pro-adipogenic and anti-adipogenic bile acids using cellular model systems in order to examine clinical application in obesity cases. In addition, Dr. Cho is working on cytotoxic and cytostatic actions of various Chinese plant extracts in human cancer cells
- Cho YC,Zheng W, and Jefcoate CR. (2004) Disruption of cell-cell contact maximally but transiently activates AhR-mediated transcription in 10T1/2 fibroblasts. Toxicol Appl Pharmacol. 199:220-238. PMID: 15364539 [PubMed – indexed for MEDLINE]
- Cho YC, Zheng W, Yamamoto M, Liu X, Hanlon PR, and Jefcoate CR. (2005). Differentiation of pluripotent C3H10T1/2 cells rapidly elevates CYP1B1 through a novel process that overcomes a loss of Ah Receptor. Arch Biochem Biophys.439:139-153. PDF PMID 15967407
- Hanlon PR, Cimafranca MA, Liu X, Cho YC, and Jefcoate CR. (2005). Microarray analysis of early adipogenesis in C3H10T1/2 cells: cooperative inhibitory effects of growth factors and 2,3,7,8-tetrachloro-dibenzo-p-dioxin. Toxicol Appl Pharmacol. 207:39-58. PDF PMID 16054899
- Cho YC and Jefcoate CR. (2004). PPARg1 Synthesis and adipogenesis in C3H10T1/2 cells depends on S-Phase progression, but does not require mitotic clonal expansion. J Cell Biochem. 91:336-353. PMID 14743393
- Hanlon PR, Ganem LG, Cho YC, Yamamoto M, and Jefcoate CR. (2003). AhR- and ERK-dependent pathways function synergistically to mediate 2,3,7,8-tetrachlorodibenzo-p-dioxin suppression of peroxisome proliferator-activated receptor-gamma1 expression and subsequent adipocyte differentiation. Toxicol Appl Pharmacol. 189:11-27. PDF PMID 12758056