The long-term goal of our laboratory team is to determine the molecular mechanisms that control cardiovascular development.
Malformations of the heart account for the largest number of human birth defects, about 1% of live births. Despite this high frequency of occurrence, the molecular mechanisms that lead to congenital heart defects remain poorly understood. Therefore, identifying and characterizing the factors that control cardiac development are important steps toward understanding the genesis of congenital heart defects and important clinical disorders such as cardiac hypertrophy and heart failure.
Specifically, we perform genome-based approaches to identify novel factors critical for normal cardiac development. Several genes necessary for cardiac development were identified, and we are currently investigating the molecular/developmental roles of these genes. We combine interdisciplinary sciences to address the fundamental questions of the cardiovascular organogenesis and cardiac disease at the molecular, cellular and developmental levels.
Embryonic stem cells provide a useful tool to study the molecular mechanisms of cardiomyogenesis. One goal of stem cell research is the development of specialized cells such as heart muscle cells. The directed differentiation of embryonic stem cells is vital to the ultimate use of such cells in the development of new therapies.
Honors & Awards
- 2008-present: Permanent member of NIH study section, Cardiovascular Differentiation and Development
- 2008: March of Dimes, Ad hoc Grant review
- 2006-2007: Temporary member of NIH study section, Cardiovascular Differentiation and Development
- 2006: NIH Special Emphasis Panel Review, Cardiac Differentiation and Development
- 2002-2006: American Heart Association Grant National Review Committee
Selected Publications (Find recent publications on PubMed)
- Mysliwiec, M.R., Carlson C.D., Tietjen, J., Hung, H., Ansari A.Z., and Lee, Y. Jarid2 (JUMONJI, AT rich interactive domain 2) regulates Notch1 expression via histone modification in the developing heart. J. Biol. Chem. 287:1235-1241, 2012. PMCID: PMC3244653.
- Brody, M.J., Hacker T., Patel, J.R., Li, F., Sadoshima, J., Tevosian, S.G., Balijepalli, R.C., Moss, R.L., and Lee, Y. Ablation of the cardiac-specific gene Leuicine-Rich repeat Containing 10 (Lrrc10) results in dilated cardiomyopathy. PLoS One, 7 (12) e51621, 2012. PMCID:PMC3517560.
- Brody, M.J., Cho, E.J., Mysliwiec, M.R., Kim T.-G., Carlson C.D., Lee, K.-H., and Lee, Y. Lrrc10is a novel cardiac-specific target gene of Nkx2.5 and GATA4. J. Mol Cell Cardiology 62:237-246, 2013. PMCID: PMC3940241.
- Pereira, R.M., Martinez, G.J., Engel, I., Barboza, B., Cruz-Guilloty, F. Ko, MG., Tsangaratou, A., Lee, Y., Kronenberg, M., Bandukwala, H.S., and Rao, A. Jarid2 is induced by TCR signaling and controls iNKT cell maturation. Nature Communications, 5:4540-4553, 2014. PMCID: PMC4314221.
- Chang, Y.-H., Ye, L., Cai, W., Lee Y., Guner, H., Lee, Y., Kamp, T.J., Zhang, J., and Ge, Y. Quantitative proteomics reveals differential regulation of protein expression in recipient myocardium after tri-lineage cardiovascular cell transplantation. Proteomics, 2015. Epub ahread of print.