Yongna Xing, PhD
Position title: Associate Professor, Oncology
Email: xing@oncology.wisc.edu
Phone: 608-262-8376
Address:
6451 WIMR
1111 Highland Ave
Research Interests
My lab is interested in elucidation of signaling pathways related to cancer using multi-disciplinary biophysics and biochemical approaches, including structural biology and proteomics, in combination with cell biology. We focus on signaling pathways that affect cancer cell metabolism and cancer cell genome integrity.
Protein phosphatase 2A (PP2A) is involved in many essential cellular functions. Deregulation of PP2A function is frequently linked to multiple types of cancer. The importance of PP2A function also resides in its crosstalk with the Tor signaling pathway, which has broad effects on cell growth and metabolism. PP2A also interacts with PML, a major component of PML-nuclear body (PML-NB) that is missing in later stage of tumors. PML is considered an important tumor suppressor and has important functions in genome integrity and as an antiviral. Structural biology in combination with biochemistry and proteomics will provide powerful tools for elucidation of the structure and function of the key components in the regulation of PP2A, Tor and PML, as well as the crosstalk among them. Results from these aspects of our research will have a direct impact on the design of therapeutics against cancer.
Selected Publications
- Guo, F., Stanevich, V., Wlodarchak, N., Jiang, L., Satyshur, K.A., Li, Y., and Xing, Y. (2014) Structural basis of PP2A activation by PTPA, an ATP-dependent activation chaperone. Cell Res. 24(2):190-203.
- Kotlo K, Xing Y, Lather S, Grillon JM, Johnson K, Skidgel RA, Solaro RJ, Danziger RS. (2014) PR65A Phosphorylation Regulates PP2A Complex Signaling. PLoS One. 9(1):e85000.
- Stanevich V, Zheng A, Guo F, Jiang L, Wlodarchak N, Xing Y. (2014) Mechanisms of the Scaffold Subunit in Facilitating Protein Phosphatase 2A Methylation. PLoS One. 9(1):e86955
- Wan L, Lu X, Yuan S, Wei Y, Guo F, Shen M, Yuan M, Chakrabarti R, Hua Y, Smith HA, Blanco MA, Chekmareva M, Wu H, Bronson RT, Haffty BG, Xing Y, Kang Y. (2014) MTDH-SND1 Interaction Is Crucial for Expansion and Activity of Tumor-Initiating Cells in Diverse Oncogene- and Carcinogen-Induced Mammary Tumors. Cancer Cell, 14;26(1):92-105.
- Guo, F., Stanevich, V., Wlodarchak, N., Jiang, L., Satyshur, K.A., Li, Y., and Xing, Y. (2014) Structural basis of PP2A activation by PTPA, an ATP-dependent activation chaperone. Cell Res. 24(2):190-203.