Prashant Rajbhandari, PhD
Assistant Professor, Principal Investigator Co-Director, Director, Metabolic Assessment Core, Diabetes, Obesity, and Metabolism Institute, Disease Mechanism and Therapeutics Program, Icahn School of Medicine at Mount Sinai Medical Hospital, Manhattan, NY
Advisor: Dr. Elaine Alarid
Graduation: 05/2013
Research Interest: Regulation of estrogen receptor-alpha by post-translational modifications in breast cancer cells
Lab Website
RAJBHANDARI LABBiography
Alumni News
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Received $4 Million Grant From NIH to Study the Role of the Mammary Gland Secretome in Metabolic Health. Dr. Rajbhandari investigating a new frontier in understanding diseases like obesity and type 2 diabetes.
- Assistant Professor, Principal Investigator Co-Director, Animal Metabolic Assessment Core Diabetes and Obesity Medical Institute (DOMI) Institute for Genomics and Multiscale Biology (IGMG) Icahn School of Medicine at Mount Sinai Medical Hospital Manhattan, NY: October 2018 – Present
- Postdoctoral Research Lab: October 2013-2018 Peter Tontonoz, MD, PhD Howard Hughes Medical Institute UCLA Research focus: Investigating molecular mediators of adipose metabolic programs and their roles in diabetes and obesity
Featured Publications
- Patel, S., Sparman, N.Z.R., Arneson, D., Alvarsson, A., Santos, L.C.,, Duesman, S., Centonze, A., Hathaway, E., Ahn, IS., Diamante, G., Cely, I., Cho, CH., Talari, N.K., Rajbhandari, A.K., Goedeke,L., Wang,P., Butte, A.J., Blanpain, C., Krishnan, KC., Lusis, A.J., Stanley, S.A, Yang, X., and Rajbhandari, P.* Mammary duct luminal epithelium controls adipocyte thermogenic programme. 2023. Nature. 620, 192-199. https://doi.org/10.1038/s41586-023-06361-5. *Corresponding and senior author.
- Patel, S., Ganbold, K., Cho, C. H., Siddiqui, J., Yildiz, R., Sparman, N., Sadeh, S., Nguyen, C. M., Wang, J., Whitelegge, J. P., Fried, S. K., Waki, H., Villanueva, C. J., Seldin, M. M., Sakaguchi, S., Ellmeier, W., Tontonoz, P., and Rajbhandari, P*. Transcription factor PATZ1 promotes white adipogenesis by controlling promoter regulatory loci of adipogenic factors. 2024. Nature Communications(Accepted). *Corresponding and senior author.
- Pamela Mattar, Andressa Reginato, Christian Lavados, Manu Kalyani, Debajyoti Das, Nuria Martinez-Lopez, Mridul Sharma, Rajasekaran Subbarayan, Elodie Picarda, Xingxing Zhang, Jinghang Zhang, Chandan Guha, Gary Schwartz, Prashant Rajbhandari*, Rajat Singh*. Insulin and leptin oscillations license food-entrained browning and metabolic flexibility.2024. Cell Reports. Volume 43, ISSUE 7, 114390. *Senior authors
- Rajbhandari, P.*,Douglas Arneson, Sydney Hart#, In Sook Ahn, Graciel Diamante, Luis Santos#, An-Chieh Feng, Brandon Thomas, Laurent Vergenes, Stephen Lee, Karen Reue, Stephen Smale, Xia Yang, and Peter Tontonoz*. Single Cell Analysis Reveals Immune Cell-Adipocyte Crosstalk Regulating the Transcription of Thermogenic Adipocytes. eLife. 2019;8:e49501 DOI: 10.7554/eLife.49501*Corresponding authors
- Rajbhandari, P., Thomas, B, Feng, A., Hong, C, Vergnes, L., Wang, J., Sallam, T., Wang, B., Sandhu, J., Seldin, MM., Lusis, AJ., Fong. L., Young, SG., Reue, K., Smale, T., and Tontonoz, P. Interleukin-10 Signaling Alters Chromatin Architecture in Adipose to Limit Thermogenesis and Energy expenditure. Cell. 2018; 172, 1, 218-233.e1; e217doi.org/10.1016/j.cell.2017.11.019