Yukiko Muroi, PhD
Instrumental Scientist Product Performance Evaluation, L’Oréal, Kanagawa, Japan
Advisor: Dr. Meyer Jackson
Graduation: 05/2006
Biography
Summary:
-Research scientist in the field of pharmacology and neuroscience. -Extensive experience in electrophysiology (two-electrode, cut-open oocyte and patch clamp) -Strong background in ligand-gated and voltage-gated ion channels -Investigated the relationships of drugs and target proteins by using fluorescence techniques -Training in organic synthetic technique, including characterization of compounds -Supervising experience to undergraduate/graduate students/postdoc for various scientific skills -Extensive experience with public speaking -Interested in research/development position in an industry setting Languages: Japanese and EnglishSkills
- Fluorescence Microscopy, Site-directed Mutagenesis, Cell Culture
- PCR, HPLC, NMR, Mass Spectrometry, Electrophysiology
- MALDI-TOF, Molecular Biology, TransfectionTissue Culture
- Immunohistochemistry, Animal Models, Chromatography
- Pharmacology, Molecular Cloning, Biophysics Spectroscopy
- Organic Synthesis, qPCR, Animal Behavior
Publications
- Muroi Y, Czajkowski C, and Jackson MB (2006). Local and global ligand-induced changes in the structure of the GABA(A) receptor. Biochemistry. 45:7013-7022. PMID: 16752892 [PubMed – indexed for MEDLINE]
- Muroi Y, Ru F, Chou YL, Carr MJ, Undem BJ, Canning BJ (2013). Selective inhibition of vagal afferent nerve pathways regulating cough using Nav 1.7 shRNA silencing in guinea pig nodose ganglia. Am J Physiol Regul Integr Comp Physiol. 304:R1017-1023. Epub 2013 Apr 10. PMID: 23576611 [PubMed – in process]
- Muroi Y, Ru F, Kollarik M, Canning BJ, Hughes SA, Walsh S, Sigg M, Carr MJ, and Undem BJ (2011). Selective silencing of Na(V)1.7 decreases excitability and conduction in vagal sensory neurons. J Physiol. 589(Pt 23):5663-5676. Epub 2011 Oct 17. PMCID: PMC3249041
- Muroi Y and Undem BJ (2011). Targeting peripheral afferent nerve terminals for cough and dyspnea. Curr Opin Pharmacol. 11:254-64. PMCID: PMC3151737
- Arcisio-Miranda M, Muroi Y, Chowdhury S, and Chanda B (2010). Molecular mechanism of allosteric modification of voltage-dependent sodium channels by local anesthetics. J Gen Physiol. 136:541-554. PMCID: PMC2964522
- Muroi Y, Arcisio-Miranda M, Chowdhury S, and Chanda B (2010). Molecular determinants of coupling between the domain III voltage sensor and pore of a sodium channel. Nat Struct Mol Biol. 17:230-237. Epub 2010 Jan 31. PMCID: PMC2879147
- Muroi Y, Theusch CM, Czajkowski C, and Jackson MB (2009). Distinct structural changes in the GABAA receptor elicited by pentobarbital and GABA. Biophys J. 96:499-509. PMCID: PMC2716461
- Muroi Y and Chanda B (2009). Local anesthetics disrupt energetic coupling between the voltage-sensing segments of a sodium channel. J Gen Physiol. 133:1-15. Epub 2008 Dec 15. Erratum in: J Gen Physiol. 133:459. PMCID: PMC2606943