University of Wisconsin–Madison

Anjon Audhya, Phd

Associate Professor, Biomolecular Chemistry, MCP Program Director

audhya@wisc.edu

608-262-3761

5214a Biochemical Sciences
440 Henry Mall

Lab Website
Audhya Lab

anjon audhya

Research Interests

Our laboratory is committed to understanding the fundamental mechanisms by which membrane proteins, lipids, and other macromolecules are transported throughout eukaryotic cells. To do so, we take advantage of numerous interdisciplinary approaches, including biochemistry, structural biology, biophysics, genetics, molecular biology and high-resolution fluorescence and electron microscopy.

Additionally, we use a variety of experimental systems, ranging from simple animal models (e.g. Caenorhabditis elegans) to human induced pluripotent stem cells (iPSCs). We also aim to recapitulate individual steps of membrane transport in vitro, using recombinant proteins and chemically defined lipids. Our ultimate goal is to identify the regulatory pathways that control membrane deformation, which enable vesicle formation in the endosomal and secretory systems. Although basic research is the cornerstone of our program, we also seek to define pathomechanisms that underlie human disease, focusing on the impact of mutations in key trafficking components that lead to cancer, neurodegeneration, asthma, and diabetes. For more information, please visit our lab webpage: www.audhyalab.org.

Honors & Awards

  • Romnes Faculty Fellowship (2017)
  • Vilas Faculty Early Career Investigator Award (2016)
  • Vilas Associate Award (2015)
  • March of Dimes Basil O’Connor Starter Scholar Award, (2010)
  • American Heart Association SDG Award, (2010)
  • Shaw Scientist Award (2010)
  • DeLill Nasser Award for Professional Development in Genetics (2006)

 

Selected Publications:

(Find further publications on PubMed)

  • Hanna, M.G., Block, S., Frankel, E.B., Hou, F., Johnson, A., Yuan, L., Knight, G., Moresco, J.J., Yates, J.R., Ashton, R., Schekman, R., Tong, Y., and Audhya, A. (2017) TFG facilitates outer coat disassembly on COPII transport carriers to promote tethering and fusion with ER-Golgi intermediate compartments. Proc. Natl. Acad. Sci. USA. In press.
  • Konig, J., Frankel, E.B., Audhya, A.,* and Muller-Reichert, T.* (2017) Membrane remodeling during embryonic abscission in Caenorhabditis elegans. J. Cell Biol. 216:  1277-1286. (* denotes co-corresponding authors)
  • Wang, L., Johnson, A., Hanna, M., and Audhya, A. (2016) Eps15 membrane binding and bending activity acts redundantly with Fcho1 during clathrin-mediated endocytosis. Mol. Biol. Cell. 27:  2676-2687. (Cover)
  • Hanna, M.G., Mela, I., Wang, L., Henderson, R.M., Chapman, E.R., Edwardson, J.M., and Audhya, A. (2016) Sar1 GTPase activity is regulated by membrane curvature. J. Biol. Chem. 291: 1014-1027.
  • Johnson, A., Bhattacharya, N., Hanna, M., Pennington, J.G., Schuh, A.L., Wang, L., Otegui, M.S., Stagg, S.M., and Audhya, A. (2015) TFG clusters COPII-coated transport carriers and promotes early secretory pathway organization. EMBO J. 34:  811-827.