Brandon Burbach, PhD
Position title: Senior Research Associate Scientist – Lab Medicine and Pathology Center for Immunology, University of Minnesota Twin Cities
Email: burba005@umn.edu
Phone: Advisor: Dr. Alan Rapraeger
Address:
Graduation: 07/2004
Research Interest: Regulation of T-cell receptor signaling and LFA-1 integrin function by adhesion and degranulaton protein (ADAP) in primary murine T-cells
Alumni News
- Burbach was one of the speakers for the Careers in Biology Alumni Speakers Series (March 2013)
- 2011 University of Minnesota Academic Health Center Seed Grant
- American Heart Association Postdoctoral Fellowship July 2007-June 2009
Minnesota Craniofacial Research Training Program, Postdoctoral Fellow - September 2004 – August 2007 (NIH Postdoctoral Fellowship
Publications
- Burbach BJ, Srivastava R, Ingram MA, Mitchell JS, and Shimizu Y. (2011)The pleckstrin homology domain in the SKAP55 adapter protein defines the ability of the adapter protein ADAP to regulate integrin function and NF-kappaB activation.J Immunol. 186:6227-6237. Epub 2011 Apr 27. PMCID: PMC3108501
- Medeiros RB,Burbach BJ, Mueller KL, Srivastava R, Moon JJ, Highfill S, Peterson EJ, and Shimizu Y. (2007) Regulation of NF-kappaB activation in T cells via association of the adapter proteins ADAP and CARMA1. Science. 316:754-758. PMID: 17478723 [PubMed – indexed for MEDLINE]
- Srivastava R, Burbach BJ, Mitchell JS, Pagán AJ, and Shimizu Y (2012) ADAP regulates cell cycle progression of T cells via control of cyclin E and Cdk2 expression through two distinct CARMA1-dependent signaling pathways. Mol Cell Biol. 32:1908-1917. Epub 2012 Mar 12. PMID: 22411628 [PubMed – in process]
- Bunnell TM, Burbach BJ, Shimizu Y, Ervasti JM. (2011) β-Actin specifically controls cell growth, migration, and the G-actin pool. Mol Biol Cell. 22:4047-4058. Epub 2011 Sep 7.PMID: 21900491 [PubMed – indexed for MEDLINE]
- Srivastava R, Burbach BJ, and Shimizu Y. (2010) NF-kappaB activation in T cells requires discrete control of IkappaB kinase alpha/beta (IKKalpha/beta) phosphorylation and IKKgamma ubiquitination by the ADAP adapter protein. J Biol Chem. 285:11100-11105. Epub 2010 Feb 17.PMID: 20164171
- Burbach BJ, Srivastava R, Medeiros RB, O’Gorman WE, Peterson EJ, and Shimizu Y. (2008) Distinct regulation of integrin-dependent T cell conjugate formation and NF-kappa B activation by the adapter protein ADAP. J Immunol. 181:4840-4851.PMID: 18802088
- Mueller KL, Thomas MS, Burbach BJ, Peterson EJ, and Shimizu Y. (2007).Links Adhesion and Degranulation-Promoting Adapter Protein (ADAP) Positively Regulates T Cell Sensitivity to Antigen and T Cell Survival. J Immunol. 179:3559-3569. PMID 17785790
- Burbach BJ, Medeiros RB, Mueller KL, and Shimizu Y. (2007). Links T-cell receptor signaling to integrins. Immunol Rev. 218:65-81. PMID 17624944