Edwin R. Chapman, Phd

Position title: Professor, Neuroscience; Investigator, Howard Hughes Medical Institute; Ricardo Miledi Professor of Neuroscience; Director of the Quantitative Membrane Biophysics Program

Email: chapman@wisc.edu

Phone: 608-263-1762

Address:
Office: 9557 WIMR 2
Mail: 5505 WIMR 2
1111 Highland Avenue
Madison, WI

HHMI Investigator
HHMI
Neuroscience Faculty Page
Neuroscience Faculty Page
Lab Website
Chapman Lab
Ed Chapman

Research Interests

Our research is focused on understanding the structure, function and dynamics of the exocytotic membrane “fusion machine” that mediates the release of neurotransmitters and hormones from neurons. We study membrane fusion using approaches that range from reconstituted fusion assays to electrophysiological measurements of synaptic transmission in brain slices. We also study myriad additional aspects of polarized membrane traffic in neurons, the mechanism of action of the clostridial neurotoxins (tetanus and botulinum toxins), and the cell biology of large dense core vesicles.

Honors & Awards

  • 2020 WARF Named Professorship
  • 2019 Sir Bernard Katz Award from the Biophysical Society
  • 2017 Member of the NIH study section SYN
  • 2015 Editorial Board, JGP
  • 2012 Kellett Mid-Career Award
  • Rose Awards (to J.B. 2003, M.D. 2004, M.C. 2008, E.H. 2009, S.E.K. 2012, H.B. 2015, C.S.E. 2016, E.B.W. 2017, M.M.B. 2020); for outstanding thesis in the neurosciences
  • 2005 HHMI Investigator
  • 2004 Romnes Award
  • 1999 Pew Scholars Award
  • 1998 Shaw Scientist Award

Research Breakthroughs

  • Bao, H. Das, D. Courtney, N. Jiang, Y. Briguglio, J. Lou, X. Roston, D. Cui, Q. Chanda B. & Chapman, E.R. (2018). Dynamics and number of Trans-SNARE complexes determine nascent fusion pore properties. Nature 554(7691): 260-263. PMID: 29420480 [PMCID in progress]
  • Courtney, N.A. Briguglio, J.S., Bradberry, M.M. & Chapman, E.R. (2018). Excitatory and inhibitory neurons utilize different Ca2+ sources and sensors to regulate spontaneous release. Neuron 98(5):977-991.e5. doi: 10.1016/j.neuron.2018.04.022. PMID: 29754754 [PMCID in progress]
  • Xue, R., Ruhl, D.A., Briguglio, J.S. & Chapman, E.R. (2018). Doc2 mediated superpriming supports synaptic augmentation. PNAS 115(24):E5605-E5613. doi: 10.1073/pnas.1802104115. PMID: 29844163 PMCID in progress]

Selected Publications:

(Find further publications on PubMed)

  • Yao, J, Gaffaney, J.D., Kwon, S.E. and Chapman, E.R. (2011). Doc2 is a Ca2+-sensor required for asynchronous neurotransmitter release.Cell 147(3):666-77. PMCID:PMC3220409
  • Hui, E., Johnson, C., Yao, J., Dunning, M. and Chapman, E.R.(2009).Synaptotagmin-mediated bending of the target membrane is a critical step in Ca2+-regulated fusion.Cell 138: 709-721.PMCID: PMC2758036
  • *Chai, Q., *Arndt, J.W., *Dong, M., Tepp, W.H., Johnson, E.A., #Chapman, E.R.and #Stevens, R.C.. (2006). Structural basis of receptor recognition by botulinum neurotoxin B.Nature 444: 1096-1100.
    *equal contribution #corresponding authors
  • Dong, M., Yeh, Y., Tepp, W.H., Dean, C., Johnson, E.A., Janz, R. andChapman, E.R.. (2006).SV2 is the protein receptor for botulinum neurotoxin A.Science312:592-596.
  • Tucker, W.T., Weber, T. and Chapman, E.R.. (2004) Reconstitution of Ca2+-triggered membrane fusion by synaptotagmin and SNAREs.Science 304: 435-438.