Jianlin Chu, Phd
Senior Scientist, Pfizer
Advisor: Dr. Emery Bresnick
Research Interest: The research is focused on investigating reprogramming of human somatic cells (generation of iPS cells) using purified proteins and their therapeutic potential as regenerative drugs. Tagged reprogramming protein candidates are expressed in mammalian, bacterial, as well as baculoviral systems and purified. Different strategies are under investigation for maximal delivery and reprogramming efficiency.
- Kim J, Woo AJ, Chu J, Snow J, Fujiwara Y, Kim CG, Cantor AB, and Orkin SH. (2010) A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs. Cell 143: 313-324.
- Orkin SH, Wang J, Kim J, Chu J, Rao S, Theunissen TW, Shen X, and Levasseur DN. (2008) The transcriptional network controlling pluripotency in ES cells. Cold Spring Harb Symp Quant Biol. 73:195-202. Review.PMID: 19478325
- Wang J, Rao S, Chu J, Shen X, Levasseur DN, Theunissen TW, and Orkin SH. (2006). A protein interaction network for pluripotency of embryonic stem cells.Nature. 444:364-8. PDF PMID 17093407
- Chu J and Bresnick EH. (2004). Evidence that C promoter-binder factor 1 binding is required for Notch-1 mediated repression of activator protein-1. J Biol Chem. 279:12337-12345. PDF PMID 14645224
- Chu J, Jeffries S, Norton JE, Capobianco AJ, and Bresnick EH. (2002). Repression of activator protein-1-mediated transcriptional activation by the Notch-1 intracellular domain. J Biol Chem. 277:7587-7597. PDF PMID 11739397
- Bresnick EH, Chu J, Christensen HM, Lin B, and Norton J. (2000). Linking notch signaling, chromatin remodeling, and T-cell leukemogenesis. J Cell Biochem.35:46-53. PMID 11389531