Molecular and Cellular Pharmacology Training Program
University of Wisconsin School of Medicine and Public Health

Uyen Chu, PhD

Position title: Captain, US Army

Email: ubchu@yahoo.com

Phone: Advisor: Dr. Arnold Ruoho

Address:
Graduation: 08/2011
Research Interest: Medical Diagnostics

Uyen Chu

Publications

  • Chu, U.B., Mavlyutov, T.A., Chu, M.L. Yang, H. Schulman, A. Mesangeau, C. McCurdy, C.R., Guo, L.W., Ruoho, A.E. (2015) The Sigma-2 receptor and Progesterone Receptor Membrane Component 1 are different binding sites derived from independent genes. EbioMedicine 2(11): 1806-1813.  PMID: 26870805.
  • Chu, U.B. and Ruoho, A.E. (2015)  Sigma Receptor Binding Assays. Curr Protoc Pharmacol. 71: 1.34.1-21. PMID: 26646191.
  • Chu, U.B. and Ruoho, A.E. (2016)  Biochemical Pharmacology of the Sigma-1 Receptor. Mol Pharmacol. 89(1): 142-53. PMID: 26560551
  •  Chu, U.B., Duellman, T., Weaver, S.J., Tao, Y., Yang, J. (2015) Endothelial protective genes induced by statin are mimicked by ERK5 activation as triggered by a drug combination of FTI-277 and GGTI-298.  Biochim Biophys Acta. 1850(7): 1415-25. PMID: 25829196.
  • Gromek K.A., Suchy F.P., Meddaugh H.R., Wrobel R.L., LaPointe L.M., Chu U.B., Primm J.G., Ruoho A.E., Senes A., Fox B.G. (2014). The Oligomeric States of the Purified Sigma 1 Receptor are Stabilized by Ligands.  J. Biol Chem. 289(29): 20333-44. PMID: 24847081.
  • Chu U.B., Vorperian S.K., Satyshur K., Eickstaedt K., Cozzi N.V., Hajipour A.R. and Ruoho A.E. (2014). Non-competitive inhibition of indolethylamine N-methyltransferase by N,N’ Dimethyltryptamine (DMT) and N,N’-dimethylaminopropyltryptamine.  Biochemistry. 53(18):2956-65. PMID: 24730580.
  • Chu U.B., Ramachandran S., Hajipour A.R., and Ruoho, A.E. (2013) Photoaffinity labeling of the Sigma-1 Receptor with N-(3-(4-nitrophenyl)-N-dodecylamine (4-NPPC12) — Evidence for Receptor Dimers. Biochemistry. 52(5): 859-68. PMID: 23324054.
  • Ruoho A.E., Chu U.B., Ramachandran S., Fontanilla D., Mavlyutov T., and Hajipour A.R. (2012) The ligand binding region of the sigma-1 receptor: studies utilizing photoaffinity probes, sphingosine and N-alkylamines. Curr. Pharm. Des. 18(7): 920 – 9. PMID: 22288412.
  • Chu U.B., Ramachandran S., Hajipour A.R., and Ruoho, A.E. (2011) Characterization of interactions of 4-nitrophenylpropyl-N-alkylamine with sigma receptors.  Biochemistry. 50(35): 7568-78. PMID: 21790129.
  • Chu U.B., Song J., Mavlyutov T.A., and Guo L.W. (2010) In Vitro Interaction of tubulin with the photoreceptor cGMP phosphodiesterase gamma-subunit. Neurosci Lett. 482(3): 225 – 9. PMID: 17622576.
  • Hajipour A.R., Fontanilla D., Chu U.B., Arbabian M. and Ruoho A.E. (2010) Synthesis and characterization of N, N-dialkyl and N-alkyl-N-aralkyl fenpropimorph-derived compounds as high affinity ligands for sigma receptors. Bioorg. Med. Chem. 18(12): 4397 – 404. PMID: 20493718.
  • Ramachandran S., Chu U.B., Mavlyutov T.A., Pal A., Pyne S., and Ruoho A.E.  (2009) The sigma-1 receptor interacts with N-alkyl amines and endogenous sphingolipids.  Eur. J. Pharmacol. 609:19-26. PMID: 19285059.
  • Fontanilla D., Hajipour A.R., Pal A., Chu U.B., Arbabian M., and Ruoho A.E. (2008) Probing the steroid binding domain-like I (SBDLI) of the sigma-1 receptor binding site using N-substituted photoaffinity labels.  Biochemistry 47(27): 7205-17. PMID: 18547058.
  • Pal A., Chu U.B., Ramachandran S., Grawoig D., Guo L.W., Hajipour A.R., and Ruoho A.E. (2008) Juxtaposition of the steroid binding domain-like I and II regions constitutes a ligand binding site in the sigma-1 receptor.  J Biol Chem. 283(28): 19646-56. PMID: 18467334.
  • Pal A., Hajipour, A.R., Fontanilla D., Ramachandran S., Chu U.B., Mavlyutov T., and Ruoho A.E.  (2007) Identification of regions of the sigma-1 receptor ligand binding site using a novel photoprobe.  Mol. Pharmacol., 72(4): 921 – 33. PMID: 17622576.