Molecular and Cellular Pharmacology Training Program
University of Wisconsin School of Medicine and Public Health

Dominique Fontanilla, PhD

Position title: Senior Director, Head of Datamonitor Healthcare (Citeline) Chicago, IL

Phone: Advisor: Dr. Arnold Ruoho

Address:
Graduation: 04/2010
Research Interest: Pharmacology and functional characterization of the sigma-1 receptor

Dominique Fontanilla

Publications

  • Pal A, Fontanilla D, Gopalakrishnan A, Chae YK, Markley JL, and Ruoho AE (2012). The sigma-1 receptor protects against cellular oxidative stress and activates antioxidant response elements. Eur J Pharmacol. 682:12-20. Epub 2012 Feb 22. PMCID:PMC3314091
  • Ruoho AE, Chu UB, Ramachandran S, Fontanilla D, Mavlyutov T, Hajipour AR (2012). The ligand binding region of the sigma-1 receptor: studies utilizing photoaffinity probes, sphingosine and N-alkylamines. Curr Pharm Des. 18:920-929. Review. PMID: 22288412
  • Johannessen M, Fontanilla D, Mavlyutov T, Ruoho AE, Jackson MB. (2011)Antagonist action of progesterone at σ-receptors in the modulation of voltage-gated sodium channels. Am J Physiol Cell Physiol. 300:C328-37. PMCID: PMC3043630
  • Hajipour AR, Fontanilla D, Chu UB, Arbabian M, and Ruoho AE (2010).Synthesis and Characterization of N, N’-dialkyl and N-alkyl-N‘-aralkyl Fenpropimorph-derived Compounds as High Affinity Ligands for Sigma Receptors. Bioorg Med Chem. 18:4397-4404. PMCID:PMC3565575
  • Fontanilla D, Johannessen M, Hajipour AR, Cozzi NV, Jackson MB, and Ruoho AE (2009). The hallucinogen N,N-dimethyltryptamine (DMT) is an endogenous sigma-1 receptor regulator.  Science. 323:934-937. PMCID:PMC2947205
  • Fontanilla D, Hajipour AR, Pal A, Chu UB, Arbabian M, and Ruoho AE (2008). Probing the steroid binding domain-like I (SBDLI) of the ˆ-1 receptor binding site using N-substituted photoaffinity labels. Biochemistry 47:7205- 7217.  PMCID:PMC3250216
  • Pal A, Hajipour AR, Fontanilla D, Ramachandran S, Chu UB,  Mavlyotov T, and Ruoho AE (2007). Identification of Regions of the Sigma-1 Receptor Ligand Binding Site Using a Novel Photoprobe. Mol Pharmacol. 72:921-933 PMID: 17622576