Andrea Galmozzi, PhD

Position title: Assistant Professor, Department of Medicine, Division of Endocrinology, Diabetes & Metabolism

Address:
3057 WIMR
1111 Highland Ave
Madison, WI 53705

Research Interests

Dr. Galmozzi’s research focuses on the identification of adipocyte functional pathways that can be pharmacologically modulated to treat metabolic disorders, including obesity and type 2 diabetes. His primary research interest is to understand how signaling metabolites, particularly endogenous ligands of nuclear receptors, are trafficked inside cells. He carries out this goal using a multidisciplinary approach encompassing physiology, chemical biology (chemoproteomics, metabolomics), molecular and cellular biology, and in vivo models of metabolic disease. Elucidation of the molecular pathways that traffic signaling metabolites will shed light on the crosstalk between metabolism and gene transcription, reveal fundamental mechanisms in cell biology and open up new avenues to modulate gene expression for therapeutic purposes.

Selected Publications

Galmozzi A, Kok BP, Kim AS, Montenegro-Burke JR, Lee JY, Spreafico R, Mosure S, Albert V, Cintron-Colon R, Godio C, Webb WR, Conti B, Solt LA, Kojetin D, Parker CG, Peluso JJ, Pru JK, Siuzdak G, Cravatt BF, Saez E. PGRMC2 is an intracellular haem chaperone critical for adipocyte function.Nature. 2019 Dec;576(7785):138-142. doi: 10.1038/s41586-019-1774-2. Epub 2019 Nov 20. PubMed PMID: 31748741; PubMed Central PMCID: PMC6895438.

Galmozzi A, Parker CG, Kok BP, Cravatt BF, Saez E. Discovery of Modulators of Adipocyte Physiology Using Fully Functionalized Fragments.Methods Mol Biol. 2018;1787:115-127. doi: 10.1007/978-1-4939-7847-2_9. PubMed PMID: 29736714; PubMed Central PMCID: PMC6010189.

Parker CG*, Galmozzi A*, Wang Y, Correia BE, Sasaki K, Joslyn CM, Kim AS, Cavallaro CL, Lawrence RM, Johnson SR, Narvaiza I, Saez E, Cravatt BF.Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19. PubMed PMID: 28111073; PubMed Central PMCID: PMC5632530. (* equal contribution)

Galmozzi A, Dominguez E, Cravatt BF, Saez E. Application of activity-based protein profiling to study enzyme function in adipocytes. Methods Enzymol. 2014;538:151-69. doi: 10.1016/B978-0-12-800280-3.00009-8. PubMed PMID: 24529438; PubMed Central PMCID: PMC4138146.

Dominguez E, Galmozzi A, Chang JW, Hsu KL, Pawlak J, Li W, Godio C, Thomas J, Partida D, Niessen S, O’Brien PE, Russell AP, Watt MJ, Nomura DK, Cravatt BF, Saez E. Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes. Nat Chem Biol. 2014 Feb;10(2):113-21. doi: 10.1038/nchembio.1429. Epub 2013 Dec 22. PubMed PMID: 24362705; PubMed Central PMCID: PMC3953460.

Galmozzi A, Sonne SB, Altshuler-Keylin S, Hasegawa Y, Shinoda K, Luijten IHN, Chang JW, Sharp LZ, Cravatt BF, Saez E, Kajimura S. ThermoMouse: an in vivo model to identify modulators of UCP1 expression in brown adipose tissue. Cell Rep. 2014 Dec 11;9(5):1584-1593. doi: 10.1016/j.celrep.2014.10.066. Epub 2014 Nov 26. PubMed PMID: 25466254; PubMed Central PMCID: PMC4268417.