University of Wisconsin–Madison

Michael L. Gonzales, Phd

Senior Product Applications Specialist, Fluidigm Corporation Biotechnology Company, San Francisco, CA

michael.gonzales@fluidigm.com

Advisor: Dr. Richard Anderson

Graduation: 04/2007
Research Interest: Regulation of epigenetic factor MECP2 and its effects on gene expression

Michael Gonzales

Alumni News

  • Applications Specialist II at Fluidigm Corporation in June 2013. The Fluidigm Corporation develops, manufactures, and markets microfluidic systems for growth markets in the life sciences and in applied markets.

Skills and Expertise

  1. Analysis of gene expression
  2. Signal transduction networks
  3. Protein expression, purification and analysis
  4. Culture of primary cells and cell lines
  5. Epigenetic regulation of gene expression

Publications

  • Gonzales ML, Adams S, Dunaway KW, and Lasalle JM (2012). Phosphorylation of Distinct Sites in MeCP2 Modifies Cofactor Associations and the Dynamics of Transcriptional Regulation. Mol Cell Biol. 32:2894-2903. PMCID: PMC341691
  • Singleton MK, Gonzales ML, Leung KN, Yasui DH, Schroeder DI, Dunaway K, and LaSalle JM (2011). MeCP2 is required for global heterochromatic and nucleolar changes during activity-dependent neuronal maturation. Neurobiol Dis. 43:190-200. PMCID: PMC3096744
  • Gonzales ML, LaSalle JM (2010). The role of MeCP2 in brain development and neurodevelopmental disorders. Curr Psychiatry Rep. 12:127-134. PMCID: PMC2847695
  • Adegbola AA, Gonzales ML, Chess A, LaSalle JM, and Cox GF (2009). A novel hypomorphic MECP2 point mutation is associated with a neuropsychiatric phenotype. Hum Genet. 124:615-623. PMID: 18989701
  • Gonzales ML, Mellman DL, Anderson RA (2008). CKIalpha is associated with and phosphorylates star-PAP and is also required for expression of select star-PAP target messenger RNAs. J Biol Chem. 283:12665-12673. PMCID: PMC62431003
  • Mellman DL, Gonzales ML, Song C, Barlow CA, Wang P, Kendziorski C, Anderson RA (2008). A PtdIns4,5P2-regulated nuclear poly(A) polymerase controls expression of select mRNAs. Nature. 451:1013-1017.PMID: 18288197