Zachery Gregorich, PhD

Position title: Staff Scientist, Dr. Wei Guo Lab, UW-Madison


Phone: Advisor: Dr. Ying Ge

Graduation: 08/2017
Research Interests: G-protein coupled receptor signaling and top-down proteomics of myofilaments in heart failure


Carlson, A., Gregorich, Z., Striker, R., 2013, “Telaprevir to boceprevir switch highlights lack of cross-reactivity,” Clinical Infectious Disease, Vol. 56, 552-554. PMCID: PMC3732052

Peng, Y., Yu, D., Gregorich, Z., Chen, X., Beyer, A.M., Gutterman, D.D., Ge, Y., 2013, “In-depth proteomic analysis of human tropomyosin by top-down mass spectrometry,” Journal of Muscle Research and Cell Motility, Vol. 34, 199-210. PMCID: PMC3849107

Zhao, D.S., Gregorich, Z.R., Ge, Y., 2013, “High throughput screening of disulfide-containing proteins in a complex mixture,” Journal of Proteomics, Vol. 13, 3256-3260. PMCID: PMC3914208

Guner, H., Close, P.L., Cai, W., Zhang, H., Peng, Y., Gregorich, Z.R., Ge, Y., 2014, “MASH Suite: a user-friendly and versatile software interface for high-resolution mass spectrometry data interpretation and visualization,” Journal of the American Society for Mass Spectrometry, Vol. 25, 464-470. PMCID: PMC3940544

Gregorich, Z.R., Ge, Y., 2014, “Top-down proteomics in health and disease: challenges and opportunities,” Journal of Proteomics, Vol. 14, 1195-1210. PMCID: PMC4100610

Gregorich, Z.R., Chang, Y.H., Ge, Y., 2014, “Proteomics in heart failure: top-down or bottom-up?,” Pflugers Archive – European Journal of Physiology, Vol. 466, 1199-1209. PMCID: PMC4037365

Peng, Y., Gregorich, Z.R., Valeja, S.G., Zhang, H., Cai, W., Chen, Y.C., Guner, H., Chen, A.J., Schwahn, D.J., Hacker, T.A., Liu, X., Ge, Y., 2015, “Top-down proteomics reveals concerted reductions in myofilament and Z-disc protein phosphorylation after acute myocardial infarction,” Molecular & Cellular Proteomics, Vol. 13, 2752-2764. PMCID: PMC4189000

Chang, Y.H., Gregorich, Z.R., Chen, A.J., Hwang, L., Guner, H., Yu, D., Zhang, J., Ge, Y., 2015, “New mass-spectrometry-compatible degradable surfactant for tissue proteomics,” Journal of Proteome Research, Vol.14, 1587-1599. PMCID: PMC4384424

Hwang, L., Ayaz-Guner, S., Gregorich, Z.R., Cai, W., Valeja, S.G., Jin, S., Ge, Y., 2015, “Specific enrichment of phosphoproteins using functionalized multivalent nanoparticles,” Journal of the American Chemical Society. PMCID: PMC4372338

Gregorich ZR, Peng Y, Lane NM, Wolff JJ, Wang S, Guo W, Guner H, Doop J, Hacker TA, Ge Y., 2015, “Comprehensive assessment of chamber-specific and transmural heterogeneity in myofilament protein phosphorylation by top-down mass spectrometry,” J Mol Cell Cardiol. PMCID: PMC4637236.

Valeja SG, Xiu L, Gregorich ZR, Guner H, Jin S, Ge Y., 2015, “Three dimensional liquid chromatography coupling ion exchange chromatography/hydrophobic interaction chromatography/reverse phase chromatography for effective protein separation in top-down proteomics,” Anal Chem. PMCID: PMC4575680.

Cai W, Guner H, Gregorich ZR, Chen AJ, Ayaz-Guner S, Peng Y, Valeja SG, Liu X, Ge Y, 2016, “MASH Suite Pro: A Comprehensive Software Tool for Top-Down Proteomics,” Mol Cell Proteomics. PMCID: PMC4739683.

Gregorich ZR, Peng Y, Cai W, Jin Y, Wei L, Chen AJ, McKiernan SH, Aiken JM, Moss RL, Diffee GM, Ge Y, 2016, “Top-down proteomics reveals decrease in myosin regulatory light chain phosphorylation that contributes to sarcopenic muscle dysfunction,” J Proteome Res., PMID: 27362462

Yu D, Peng Y, Ayaz-Guner S, Gregorich ZR, Ge Y, 2016, “Comprehensive Characterization of AMP-Activated Protein Kinase Catalytic Domain by Top-Down Mass Spectrometry,” J Am Soc Mass Spectrom. PMCID: PMC4840101.

Cai W, Tucholski TM, Gregorich ZR, Ge Y, 2016, “Top-down Proteomics: Technology Advancements and Applications to Heart Diseases,” Expert Rev Proteomics. PMID: 27448560. PMCID: PMC5026638