Brian Hoffmann, PhD
Position title: Assistant Professor, Department of Medicine, Division of Cardiology Biology and Bioengineering Center Medical College of Wisconsin, Milwaukee, WI
Email: bhoffmann@mcw.edu
Phone: Advisor: Dr. Deane Mosher
Address:
Graduation: 08/2010
Research Interest: Postdoc Industry Consultants (PICO): A biotechnology initiative of MCW
Specialties
- Proficient in Mass Spectrometry and analysis software… specifically LTQ, LTQ-FT ICR, Orbitrap, and MALDI-TOF/TOF technologies. Analysis software includes Xcalibur, BioWorks/Sequest, Mascot, and Protein Prospector, among others.
- Proficient in high performance and fast performance liquid chromatography among other purification methodologies
- Molecular biology, microbiology, biochemistry, sequence homology modeling, and cell culture experience, fluorescence microscopy
- Dr. Brian Hoffmann receives Excellence in Science Award
Awards
- T32 NIH Postdoctoral Fellow Training Grant at MCW Biotechnology and Bioengineering Center… 2010-Present
- Recipient of ‘Thrombospondins and Extracellular Matrice Proteins’ FASEB Conference Travel Award… 2010
Publications
- Hoffmann BR, El-Mansy MF, Sem DS, and Greene AS (2012). Chemical proteomics-based analysis of off-target binding profiles for rosiglitazone and pioglitazone: clues for assessing potential for cardiotoxicity. J Med Chem. 55:8260-8271. PMID: 22970990
- Hoffmann BR, Liu Y, and Mosher DF (2012). Modification of EGF-like module 1 of thrombospondin-1, an animal extracellular protein, by O-linked N-acetylglucosamine. PLoS One. 7:e32762. Epub 2012 Mar 5. PMCID: PMC3293841
- Hoffmann BR, Liu Y, and Mosher DF (2012). IGD motifs, which are required for migration stimulatory activity of fibronectin type I modules, do not mediate binding in matrix assembly. PLoS One. 7:e30615. Epub 2012 Feb 15. PMCID: PMC3280255
- Hoffmann BR, Annis DS, and Mosher DF (2011). Reactivity of the N-terminal region of fibronectin protein to transglutaminase 2 and factor XIIIA. J Biol Chem. 286:32220-32230. PMCID: PMC3173148
- Xu J, Maurer LM, Hoffmann BR, Annis DS, and Mosher DF (2010). iso-DGR sequences do not mediate binding of fibronectin N-terminal modules to adherent fibronectin-null fibroblasts. J Biol Chem. 285:8563-8571. PMCID: PMC2838278