Molecular and Cellular Pharmacology Training Program
University of Wisconsin School of Medicine and Public Health

Troy Hornberger, PhD

Position title: Professor, Comparative Biosciences

Email: thornb1@svm.vetmed.wisc.edu

Phone: 608-890-2174

Address:
4256 Veterinary Sciences

Lab Website
Hornberger Lab
Troy Hornberger

Research Interests

It is well recognized that mechanical stimuli play a major role in the regulation of skeletal muscle mass, and that the maintenance of muscle mass contributes significantly to disease prevention and the quality of life. Although the link between mechanical signals and the regulation of muscle mass has been recognized for decades, the molecular mechanisms that drive this process remain poorly defined. Hence, the long-term goal of our research is to determine how skeletal muscles sense mechanical information and convert this stimulus into the molecular events that regulates changes in muscle mass (i.e., mechanotransduction). For more details, please visit the labs main website https://www.vetmed.wisc.edu/lab/hornberger/research/.

Honors & Awards

  • Vilas Associate Award
  • Ruth L. Kirschstein National Research Service Award
  • American Federation of Aging Research, Glenn Scholar

Selected Publications

(For a complete list of publications click here)

  • Jorgenson KW, Phillips SM, and Hornberger TA. Identifying the Structural Adaptations that Drive the Mechanical Load-Induced Growth of Skeletal Muscle: A Scoping Review. Cells. 2020 Jul 9;9(7):E1658. * Obtained an Altmetric attention score of 125 (4th highest ever for the journal) within 1 month of publication. https://www.mdpi.com/2073-4409/9/7/1658/htm
  • Ogasawara R, Jensen TE, Goodman CA, Hornberger TA. Resistance Exercise-Induced Hypertrophy: A Potential Role for Rapamycin-Insensitive mTOR. Exerc Sport Sci Rev. 2019  Jul;47(3):188-194. * Highlighted by the Editor-in-Chief and selected as the ‘Journal Club’ article for the quarterly issue. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659995/
  • You, JS†, McNally RM†, Jacobs BL*, Privett RE, Gundermann DM, Lin KH, Steinert ND, Goodman CA, and Hornberger TA. The role of raptor in the mechanical load-induced regulation of mTOR signaling, protein synthesis, and skeletal muscle hypertrophy. FASEB J. 2019 Mar;33(3):4021-4034. * Obtained an Altmetric attention score of 102 (top 2%) within 7 days of publication. † equal contribution.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404572/
  • You, JS, Dooley MS, Kim CR, Kim EJ, Xu W, Goodman CA, and Hornberger TA, A DGKzeta-FoxO-ubiquitin proteolytic axis controls fiber size during skeletal muscle remodeling. Sci Signal, 2018 May 15; 11(530). pii: eaao6847. * Recommended by the Faculty of 1000.  http://stke.sciencemag.org/content/11/530/eaao6847.long
  • Potts GK, McNally RM, Blanco R, You JS, Hebert AS, Westphall MS, Coon JJ, and Hornberger TA. A Map of the Phosphoproteomic Alterations that occur after a bout of Maximal Intensity Contractions. J. Physiol. 2017 Aug 1;595(15):5209-5226. * Selected for two different commentary articles. https://physoc.onlinelibrary.wiley.com/doi/abs/10.1113/JP273904.