Troy Hornberger, PhD
Associate Professor, Comparative Biosciences
4256 Veterinary Sciences
- Lab Website
- Hornberger Lab
My overall research interest is to determine how skeletal muscles sense mechanical information and convert this stimulus into the molecular events that regulate changes in muscle mass. This interest has led me to study a protein kinase called the mammalian target of rapamycin (mTOR). Signaling by mTOR is necessary for mechanically-induced growth of skeletal muscle, and I have recently determined that mechanical stimuli activate mTOR signaling through a unique mechanism involving phospholipase D and the lipid second messenger phosphatidic acid (PLD!íPA!ímTOR). Based on this observation, my lab has focused on three projects which are all aimed at further defining how mechanical stimuli activate the PLD!íPA!ímTOR pathway and skeletal muscle growth.
Honors & Awards
- Vilas Associate Award
- Ruth L. Kirschstein National Research Service Award
- American Federation of Aging Research, Glenn Scholar
- Potts GK, McNally RM, Blanco R, You JS, Hebert AS, Westphall MS, Coon JJ, and Hornberger TA. A Map of the Phosphoproteomic Alterations that occur after a bout of Maximal Intensity Contractions. J. Physiol. [Epub ahead of print]. PMID – 28542873
- Jacobs BL, McNally RM, Kim KJ, Blanco R, Privett RE, You JS, and Hornberger TA. Identification of Novel Phosphorylation Sites on Tuberin (TSC2) that Regulate the Activation of Signaling by the Mammalian Target of Rapamycin (mTOR). J. Biol. Chem. 2017 Apr 28;292(17):6987-6997. PMCID – PMC5409467
- You JS, Anderson GB, Dooley MS, and Hornberger TA. The Role of mTOR Signaling in the Regulation of Protein Synthesis and Muscle Mass During Immobilization. Dis. Model. Mech. 2015 Sep 1;8(9):1059-69. PMCID – PMC4582099
- You JS, Lincoln HC, Kim CR, Frey, JW, Goodman CA, Zhong XP and Hornberger TA. The Role of Diacylglycerol Kinase ζ and Phosphatidic Acid in the Mechanical Activation of Mammalian Target of Rapamycin (mTOR) Signaling and Skeletal Muscle Hypertrophy. J. Biol. Chem. 2014 Jan 17;289(3):1551-63. PMCID – PMC3894336
- You JS, Dooley MS, Kim CR, Goodman CA, and Hornberger TA. A novel DGKζ-FoxO-ubiquitin proteolytic axis controls fiber size during skeletal muscle remodeling. Cell Reports. Under Review: Available at Cell Press Sneak Peek.