University of Wisconsin–Madison

Randall Kimple, MD, PHD

Assistant Professor, Human Oncology

rkimple@humonc.wisc.edu

608-263-3611

3107 WI Insitute Medical Research
1111 Highland Ave

Randall Kimple

Research Interests

We are interested in two fundamental questions related to the biology of HPV-associated cancers. Our research is inspired by patients I see in clinic who are challenged by their diagnosis of head and neck cancer.We utilize both cell culture of HPV-positive cancer cell lines and immortalized oral epithelial cells engineered to express the individual HPV oncoproteins, and a powerful patient-derived xenograft system. Ultimately we hope that our research improves outcomes and/or decreases toxicity for patients with these cancers.

Our initial questions is: How do the HPV oncoproteins contribute to increased sensitivity to radiation in head and neck cancers. Thus far, we have identified a role for both HPV-16 E6 and HPV-16 E7 in enhancing sensitivity to radiation in head and neck cancer. Future work seeks to better understand the contributions of the individual oncogenes to the improved outcomes seen in patients.

Our second question is: Why do patients with HPV-positive head and neck cancers tend to present with a high burden of lymph node disease? To this end we are investigating cancer initiating cells the the role they may play in this invasive phenotype using our standard model systems.

Honors & Awards

  • 2010-2012 – Kaye Fellow in Head and Neck Cancer Research
  • 2012 – Best Oral Abstract Award, 3rd place Division for Integrative Systems, Translational and Clinical Pharmacology, American Society for Pharmacology and Experimental Therapeutics
  • 2008-2010 Chief Resident, Department of Radiation Oncology, University of North Carolina
  • 2002 – University of North Carolina Lineberger Comprehensive Cancer Center, Graduate Fellow Award

Selected Publications

(Find further publications on PubMed)