Michelle Kimple, PhD
Position title: Associate Professor, Medicine (Division of Endocrinology, Diabetes & Metabolism), Dirctor of the Basic Science Selective, Academic Affairs, UW SMPH
4148 UW Medical Foundation Centennial Building
1685 Highland Ave
- Lab Website
- Kimple Lab
Research in the Michelle Kimple lab is focused on how the endocrine cells of the pancreatic islet of Langerhans coordinate to regulate hormone secretion in response to glucose and other stimuli; impacting whole-body fuel metabolism. The Kimple Lab is especially interested in elucidating how G protein signaling networks regulate alpha-, beta-, and delta-cell function and their response to insults such as hyperglycemia, dyslipidemia, and inflammation (coincident with insulin resistance and type 2 diabetes) or immune infiltration (coincident with type 1 diabetes). The premise behind research in the Kimple lab is G protein-coupled receptors and their associated ligands, G proteins, and downstream effectors play key roles in early islet cell adaptation and resilience to external stressors, and that certain G protein signaling pathways become dysfunctional in the diabetic state, actively contributing to the pathophysiology of the disease and impacting the ability of certain classes of diabetes therapeutics to properly control blood glucose levels. It is the long-term goal of the Kimple Lab research program to identify and validate novel therapeutic targets to prevent or ameliorate the islet cell dysfunction of diabetes, improving the care and treatment of individuals with diabetes or preventing the disease in individuals with an underlying susceptibility.
Honors & Awards
- Vilas Life Cycle Professorship, UW-Madison Women in Science & Engineering Leadership Institute (WISELI) & Office of the Provost, 2018
“The COX-2/PGE2/EP3/Gi/o/cAMP/GSIS Pathway in the Islet: The Beat Goes On,” Commentary by R. Paul Robertson on Neuman et al., 2017, Diabetes 66: 1572-85.
- UW-Madison Department of Medicine Puestow Research Award (Given to a junior member of the Medicine faculty who has made a significant research contribution towards advancing the field of medicine), 2016
- American Society for Pharmacology and Experimental Therapeutics (ASPET) Translational and Clinical Pharmacology Division Early Career Faculty Showcase, Experimental Biology, 2016
- Featured Article of the May, 2016, Molecular Endocrinology Issue and the Endocrine Society’s 2016 “Molecular Endocrinology Outstanding Publication by a Trainee (Allison Brill)
- Nominee, UW-Madison Award for Excellence in Undergraduate Mentoring, 2015
- Mentor, American Diabetes Association Undergraduate Internship Award (Mark Cadena), 2015
- Mentor, ASPET Zannoni Summer Undergraduate Research Fellowship (SURF) Award (Allison Brill), 2013
- Mentor, UW-Madison Hilldale Undergraduate/Faculty Research Fellowship (Harpreet Brar), 2012
- American Society for Biochemistry and Molecular Biology (ASBMB)/Journal of Biological Chemistry Best Poster Award, Drug Development Category, Experimental Biology, 2012
- Kimple, M.E.#, Moss, J.L., Brar, H.K., Rosa, T., Pasker, R.L., Truchan, N.A., Newgard, C.B., and Casey, P.J. (2012). Deletion of Gαz protein protects against diet-induced glucose intolerance via expansion of β-cell mass. Journal of Biological Chemistry 287(24): 20344-55. #corresponding author
- Kimple, M.E.#, Keller, M.P., Rabaglia, M.R., Pasker, R.L., Neuman, J.C., Truchan, N.A., Brar, H.K., and Attie, A.D.#(2013) Prostaglandin E2 Receptor, EP3, Is Induced in Diabetic Islets and Negatively Regulates Glucose- and Hormone-Stimulated Insulin Secretion. Diabetes 64, 1904-12. #co-corresponding author. (A: 80%; B: 50%; C: 80%; D: 80%). I served as first and co-corresponding author, sole guarantor of the work, was primary mentor to the italicized authors, and contributed to all aspects of this work. I conceived and initiated this work in collaboration with the Attie group fully in my independent position.
- Pierre, J.F.†, Neuman, J.C.†, Brill, A.L., Brar, H.K., Thompson, M.F., Cadena, M.T., Connors K.M., Busch, R.A., Heneghan, A.F., Cham, C.M., Jones, E.K., Kibbe, C.R., Davis, D.B., Groblewski, G.E., Kudsk, K.A., and Kimple, M.E. (2015) The Gastrin Releasing Peptide Analog, Bombesin, Preserves the Exocrine Pancreas and Enteroendocrine Cell-Pancreas Axis during Parenteral Nutrition. American Journal of Physiology: Gastrointestinal and Liver Physiology 309: G431-42. †co-first authors.
- Neuman, J.C., Fenske, R.J., and Kimple M.E. (2016) Dietary polyunsaturated fatty acids and their metabolites: Implications for diabetes pathophysiology, prevention, and treatment. Nutrition and Healthy Aging4(2): 127-40.(A: 80%; B: 0%; C: 0%; D: 30%). This is an invited review article. I served as senior and corresponding author and primary graduate mentor to the other two authors.
- * Brill, A.L., Wisinski, J.A., Cadena, M.T., Thompson, M.R., Fenske, R.J., Brar, H.K., Schaid, M.D., Pasker, R.L., and Kimple, M.E.(2016) Synergy Between Gαz Deficiency and GLP-1 Analog Treatment in Preserving Functional Beta-cell Mass in Experimental Diabetes. Molecular Endocrinology 30: 543-56. Featured Article of the May 2016 Issue Endocrine Society’s 2016 “Molecular Endocrinology Outstanding Publication by a Trainee”
- * Neuman, J.C., Schaid, M.D., Brill, A.L., Fenske, R.J., Kibbe, C.R., Fontaine, D.A., Sdao, S.M.,Brar, H.K., Connors, K.M., Wienkes, H.N., Eliceiri, K.W., Merrins, M.J., Davis, D.B., andKimple, M.E.(2017) Enriching Islet Phospholipids with Eicosapentaenoic Acid Reduces Prostaglandin E2 Signaling and Enhances Diabetic β-cell Function. Diabetes 66: 1572-85. Cover Image Selected for the Print Issue Commentary on article found in: Robertson, R.P. (2017) Diabetes 66: 1464-66.
- * Fenske, R.J.†, Cadena, M.T.†, Harenda, Q.E., Wienkes, H.N., Carbajal, K., Schaid, M.D., Laundre, E., Brill, A.L., Truchan, N.A., Brar, H., Wisinski, J.A., Cai, J., Graham, T.E., Engin, F., and Kimple, M.E.(2017) The inhibitory G-protein α-subunit, Gαz, promotes Type 1 diabetes-like pathophysiology in NOD mice. Endocrinology 158(6): 1645-58. †co-first authors.
- Schaid, M.D., Wisinski, J.A., andKimple, M.E. (2017) The EP3 receptor/Gz signaling axis as a therapeutic target for diabetes and cardiovascular disease. The AAPS Journal 19(5): 1276-1283. (A: 80%; B: 0%; C: 0%; D: 10%). This is an invited review article. I served as senior and corresponding author and primary mentor to the other two authors (italicized).
- Fenske, R.J. and Kimple M.E. (2018) Targeting dysfunctional beta-cell signaling for the potential treatment of type 1 diabetes mellitus. Experimental Biology and Medicine: 243(6): 586-591.