University of Wisconsin–Madison

Dudley Lamming, Phd

Assistant Professor, Medicine, Division of Endocrinology, Diabetes and Metabolism

dlamming@medicine.wisc.edu

608-256-1901

Veterans Administration Hosp
2500 Overlook Terrace

Lab Website
Lamming Lab

Research Interests

Our goal is to understand how nutrient-responsive signaling pathways can be harnessed to promote health and longevity. Rapamycin, an inhibitor of the protein kinase mTOR, can improve both health and longevity in model organisms including mammals. Understanding and manipulating the mTOR signaling pathway through dietary, pharmaceutical or genetic interventions may provide insight into the treatment of age-related diseases, including diabetes, Alzheimer’s disease, cancer, and Hutchinson-Gilford Progeria Syndrome.

Honors & Awards

2012 – Pathway to Independence Award (K99/R00), NIH/National Institute on Aging
2015 – Glenn Award for Research in Biological Mechanisms of Aging
2015 – Progeria Research Foundation Innovator Award
2016 – Wisconsin Partnership Program New Investigator Program Award
2016 – Central Society for Clinical and Translational Research – Early Career Development  Award
2017 – Elected Fellow, Gerontological Society of America
2017 – Elected to the Board of Directors, American Aging Association

Selected Publications

(Full Publication List)

Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health, Cell Reports, 2016

mTOR: The Grand ConducTOR of Metabolism and Aging, Cell Metabolism, 2016

Intermittent administration of rapamycin extends the lifespan of female C57BL/6J mice, JGBS, 2016

Sex- and tissue-specific changes in mTOR signaling with age in C57BL/6J mice, Aging Cell, 2015

Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system, Aging Cell, 2015