Molecular and Cellular Pharmacology Training Program
University of Wisconsin School of Medicine and Public Health

A. Soren Leonard, PhD

Position title: Patent Examiner (Pharmacology), US Patent and Trademark Office, Alexandria, VA

Phone: Advisor: Dr. Johannes Hell

Address:
Graduation: 02/2001
Research Interest: Acid-sensing ion channels (ASICs)

A Soren Leonard

Alumni News

  • After graduating in 2001, Leonard served as a post-doctoral fellow with Dr. J McNamara at Duke University’s Department of Neurobiology. He now works as a senior research associate.

Publications

  • Leonard AS, Mikati MA (2010). What Is Their Fate after Magnesium Sulfate?Neonatology. 98:206-207. [Epub ahead of print] No abstract available. PMID: 20234146
  • Leonard AS, McNamara JO (2007). Does epileptiform activity contribute to cognitive impairment in Alzheimer’s disease? Neuron. 2007 55:677-678.PMID: 17785172
  • Merrill MA, Malik Z, Akyol Z, Bartos JA, Leonard AS, Hudmon A, Shea MA, Hell JW (2007). Displacement of alpha-actinin from the NMDA receptor NR1 C0 domain By Ca2+/calmodulin promotes CaMKII binding. Biochemistry. 46:8485-8497. Epub 2007 Jun 30. PMCID: PMC2547089
  • Leonard AS and McNamara JO (2007). Does epileptiform activity contribute to cognitive impairment in Alzheimer’s disease?  Neuron. 55:677-678. PMID:17785172
  • Merrill MA, Malik Z, Akyol Z, Bartos JA, Leonard AS, Hudmon A, Shea MA, Hell JW (2007). Displacement of alpha-actinin from the NMDA receptor NR1 C0 domain By Ca2+/calmodulin promotes CaMKII binding.  Biochemistry.  46:8485-8497. PMID 17602661
  • McNamara JO, Huang YZ, and Leonard AS (2006). Molecular signaling mechanisms underlying epileptogenesis. Sci STKE. 2006(356):re12. Review. PMID:17033045
  • Hruska-Hageman AM, Benson CJ, Leonard AS, Price MP, Welsh MJ (2004).PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current. J Biol Chem. 279:46962-46968. PMID:15317815
  • Yermolaieva O, Leonard AS, Schnizler MK, Abboud FM, and Welsh MJ (2004).Extracellular acidosis increases neuronal cell calcium by activating acid-sensing ion channel 1a.  Proc Natl Acad Sci USA. 101:6752-6757. PMCID: PMC404117
  • Wemmie JA, Coryell MW, Askwith CC, Lamani E, Leonard AS, Sigmund CD, and Welsh MJ (2004). Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior.  Proc Natl Acad Sci USA. 101:3621-3626. PMCID: PMC373512
  • Liu L, Leonard AS, Motto DG, Feller MA, Price MP, Johnson WA, Welsh MJ (2003). Contribution of Drosophila DEG/ENaC genes to salt taste. Neuron. 39:133-146.  PMID:12848938
  • Leonard AS, Yermolaieva O, Hruska-Hageman A, Askwith CC, Price MP, Wemmie JA, Welsh MJ (2003). cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1. Proc Natl Acad Sci USA. 100:2029-2034. PMCID: PMC149953
  • Leonard AS, Bayer KU, Merrill MA, Lim IA, Shea MA, Schulman H, and Hell JW (2002). Regulation of Calcium/Calmodulin-dependent protein kinase II docking to N-Methyl-D-aspartate receptors by calcium/calmodulin and a-actinin. J Biol Chem. 277:48441-48448. PDF PMID:12379661
  • Bayer KU, De Koninck P, Leonard AS, Hell JW, and Schulman H (2001).Interaction with the NMDA receptor locks CaMKII in an active conformation.Nature. 411:801-805. PDF PMID:11459059
  • Valtschanoff JG, Burette A, Davare MK, Leonard AS, Hell J, and Weinberg RJ (2000). SAP 97 concentrates at the postsynaptic density in cerebral cortex. Eur J Neurosci. 12:3605-3614. PDF PMID:11029631
  • Leonard AS, Lim IA, Hensworth D, Horn MC, and Hell JW (1999). CaMKII is associated with NMDA receptor. PNAS. 96:3239-3244. PDF PMCID: PMC15926
  • Leonard AS, Davare MK, Horn MC, Garner GC, and Hell JW (1998). SAP 97 interacts with the AMPA receptor GluR1 subunit. J Biol Chem. 273:19518-19524. PDF PMID:9677374
  • Leonard AS and Hell JW (1997). PKA and PKC phosphorylate the NMDA receptor at different sites. J Biol Chem. 272:12107-12115. PDF PMID:9115280
  • Coleman JS and Leonard AS (1995). Why it matters where a folivore feeds.Oecologia. 101:324-328.