Angela Mabb, PhD

Position title: Associate Professor, Neuroscience, Georgia State University


Website: Mabb Lab

Phone: Advisor: Dr. Shigeki Miyamoto

Graduation: 03/2007

Angela Mabb

Alumni News

  • Dr. Mabb joined the faculty at Georgia State University in 2016 and is currently Associate Professor at the Neuroscience Institute and Center for Behavioral Neurosciences.
  • Postdoctoral Fellow, University of North Carolina, 2011 – 2016
  • Postdoctoral Fellow, Duke University, 2007 – 2011


Complete List of Published Work in My Bibliography:

  1. Wall MJ, Collins DR, Chery SL, Allen ZD, Pastuzyn ED, George AJ, Nikolova VD, Moy SS, Philpot BD, Shepherd JD, Müller J, Ehlers MD, Mabb AM#9, Corrêa SAL#. The temporal dynamics of Arc expression regulate cognitive flexib  Neuron. 2018 May 24. pii: S0896-6273(18)30384-2. doi: 10.1016/j.neuron.2018.05.012.
  2. George AJ, Hoffiz YC, Charles AJ, Zhu Y, and Mabb AM. A comprehensive atlas of E3 ubiquitin ligase mutations in neurological   Frontiers in Genetics. 2018 Feb 14;9:29. doi: 10.3389/fgene.2018.00029. eCollection 2018. Invited Review.
  1. Mabb AM# and Ehlers MD#. Arc ubiquitination in synaptic   Seminars in Cell and Developmental Biology.  2018 May;77:10-16. doi: 10.1016/j.semcdb.2017.09.009. Epub 2017 Sep 7. Invited Review.
  1. Mabb AM, Simon JM, King IF, Lee HM, An LK, Philpot BD, Zylka MJ. Topoisomerase 1 regulates gene expression in neurons through cleavage complex-dependent and -independent mechanisms.  PLOS ONE.    11(5): e0156439.  Doi:10.1371/journal.pone.0156439.  eCollection 2016.
  1. Mabb AM, Kullmann PH, Twomey MA, Miriyala J, Philpot BD, Zylka MJ. Topoisomerase 1 inhibition reversibly impairs synaptic function.  Proceedings of the National Academy of Sciences.  2014 Dec 2;111(48):17290-5.
  1. Mabb AM*, Je HS*, Wall MJ, Robinson CG, Larsen RS, Qiang Y, Corrêa SA, and Ehlers MD. Triad3A regulates synaptic strength by ubiquitination of Arc.  Neuron2014 Jun 18;82(6):1299-316.
  2. King IF, Yandava CN, Mabb AM, Hsiao JS, Huang HS, Pearson BL, Calabrese JM, Starmer J, Parker JS, Magnuson T, Chamberlain SJ, Philpot BD, Zylka MJ. Topoisomerases Facilitate Transcription of Long Genes Linked to Autism.  Nature.  2013 Sep 5;501(7465):58-62.
  3. Peixoto RT, Kunz PA, Kwon H, Mabb AM, Sabatini BL, Philpot BD, Ehlers MD. Trans-Synaptic Signaling by Activity-Dependent Cleavage of Neuroligin-1.  Neuron.  2012 Oct;76(2):396-409.
  4. Huang H-S*, Allen JA*, Mabb AM, King IF, Miriyala JL, Taylor-Blake B, Sciaky N, Dutton JW, Lee H-M, Chen X, Jin J, Bridges AS, Zylka MJ, Roth BL, Philpot BD. Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons.  Nature.  2011 Dec 21;481(7380):185-9.
  5. Lee MH, Mabb AM, Gill GB, Yeh ET, and Miyamoto S. NF-B Induction of the SUMO Protease SENP2: A Negative Feedback Loop to Attenuate Cell Survival Response to Genotoxic Stress.  Molecular Cell.  2011 Jul 22;43(2):180-91.
  6. Yang Y, Xia F, Hermance N, Mabb A, Simonson S, Morrissey S, Gandhi P, Munson M, Miyamoto S, Kelliher MA. A cytosolic ATM/NEMO/RIP1 complex recruits TAK1 to mediate the NF-B and p38 MAP kinase/MAPKAP-2 responses to DNA damage.  Molecular and Cellular Biology.  2011 Jul;31(14):2774-86.
  1. Mabb AM and Ehlers MD. Ubiquitination in postsynaptic function and plasticity.  Annual Review of Cell and Developmental Biology.  2010 Nov 10;26:179-210.
  2. Mabb AM and Miyamoto S. SUMO and NF-B Ties.  Cell Mol Life Sci. 2007 Aug;64(15):1979-96. Review.
  1. Mabb AM, Wuerzberger-Davis SM, Miyamoto S. PIASy mediates NEMO sumoylation and NF-B activation in response to genotoxic stress.  Nature Cell Biology.  2006 Sep:8(9):986-93.
  2. Wu ZH, Mabb A, Miyamoto S. PIDD: A Switch Hitter.  Cell. 2005 Dec 16:123(6):980-2.
  3. Shi Y, Venkataraman SL, Dodson GE, Mabb AM, LeBlanc S, Tibbetts RS. Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress.  Proceedings of the National Academy of Sciences.  2004 Apr 20;101(16):5898-903.

# = Corresponding author

* = First author

9 = Lead author