Matthew Marengo, PhD
Position title: Discovery Team Lead, Enabling Technologies, Bayer Crop Science, St. Louis, MO
Phone: Advisor: Dr. David Wassarman
Research Interest: Tissue-specific gene expression in model and crop plants, molecular mechanisms that lead to specificity
- Matthew recently received a patent – Marengo, M.S., and Garcia-Blanco, M.A., inventors; Duke University, assignee. (2016). Synthetic regulation of gene expression. US patent 9,284,575.
- Matthew Marengo previously worked at GrassRoots Biotechnology: GrassRoots’ mission is to employ cutting-edge expertise in agricultural biotechnology to create better biofuel, food and industrial crops. GrassRoots is an agricultural biotechnology company that utilizes a Systems Biology approach to develop novel and valuable crop lines for the biofuel, food and industrial markets. The company, formed in 2007, intends to commercialize innovations and expertise developed by Dr. Philip Benfey at Duke University. Dr. Benfey is one of the world leaders in the fields of genomics and development. His research in the areas of plant genomics and plant root development form the core of our technologies, which will provide a competitive advantage in bringing new products to the agricultural markets.
- Formerly:Research Fellow at Duke University Medical Center from September 2008 – December 2011 (3 years 4 months) Matt studied how signaling pathways in the tumor microenvironment regulate gene expression at the level of alternative splicing.
- Campus wide: 1 year of T32 Molecular Cancer Training Grant funding.
- National: 2 years of NRSA (limited to 2 because of T32 above).
Bauer, M.J., Kanizay, L., Lamb, J., Marengo, M.S., O’Brien, B.O., inventors; Monsanto Technology LLC, assignee. (2021). Increasing gene editing and site-directed integration events utilizing meiotic and germline promoters. US patent application 17/470,784.
- To, J.P.C., Davis, I.W., Marengo, M.S., Shariff, A.S., Baublite, C., Decker, K., Galvão, R. M., Gao, Z., Haragutchi, O., Jung, J.W., Li, H., O’Brien, B., Sant, A., and Elich, T.D. (2021). Expression Elements Derived From Plant Sequences Provide Effective Gene Expression Regulation and New Opportunities for Plant Biotechnology Traits. Front. Plant Sci. 12, 712179.
- Bage, S.A., Barten, T.J., Brown, A.N., Crowley, J.H., Deng, M., Fouquet, R., Gomez, J.R., Hatton, T.W., Lamb, J.C., LeDeaux, J.R., Lemke, B.M., Manjunath, S., Marengo, M.S., Morales, E.Y., Oyervides Garcia, M., Peevers, J.M., Pellet, J.L., Rojas Avendano, A., Rymarquis, L.A., Sridharan, K., Valentine, M.F., Yang, D.H., Cargill, E.J. (2019). Genetic characterization of novel and CRISPR-Cas9 gene edited maize brachytic 2 alleles. Plant Gene 21, 100198.
- Somarelli, J.A., Schaeffer, D., Marengo, M.S., Bepler, T., Rouse, D., Ware, K.E., Hish, A.J., Zhao, Y., Buckley, A.F., Epstein, J.I., Armstrong, A.J., Virshup, D.M., and Garcia-Blanco, M.A. (2016). Distinct routes to metastasis: plasticity-dependent and plasticity-independent pathways. Oncogene 35, 4302-4311.
- Robinson, T.J, Forte, E., Salinas-Mondrigan, R., Puri, S., Marengo, M., Garcia-Blanco, M.A., Luftig, M. (2012). SplicerEX: a tool for the automated detection and classification of mRNA changes from conventional and splice sensitive microarray expression data. RNA 18, 1435-1445.
- Armstrong AJ, Marengo MS, Oltean S, Kemeny G, Bitting RL, Turnbull JD, Herold CI, Marcom PK, George DJ, and Garcia-Blanco MA (2011). Circulating tumor cells from patients with advanced prostate and breast cancer display both epithelial and mesenchymal markers. Mol Cancer Res. 9:997-1007. MCR-10-0490. PMCID: PMC3157566
- Marengo MS* and and Garcia-Blanco, MA* (2009). Shedding UV light on alternative splicing. Cell. 137:600-602. PMID: 19450507.
- Katzenberger RJ, Marengo MS, and Wassarman DA (2009). Control of alternative splicing by signal-dependent degradation of splicing-regulatory protein J Biol Chem. 284:10737-10746. PMCID: PMC2667761
- Marengo MS and Wassarman DA (2008). A DNA damage signal activates and
derepresses exon inclusion in Drosophila TAF1 alternative pre-mRNA splicing. RNA. 14:1681-1695. PMCID: PMC2491473
- Katzenberger RJ, Marengo MS, and Wassarman DA (2006). ATM and ATR pathways signal alternative splicing of Drosophila TAF1 pre-mRNA in response to DNA damage. Mol Cell Biol. 26:9256-9267. PMCID: PMC1698527
- Wagner ED, Marengo MS, and Plewa MJ (2003). Modulation of the mutagenicity of heterocyclic amines by organophosphate insecticides and their metabolites. Mutat Res. 536:103-115.