Darcie L. Moore, PhD

Position title: Associate Professor, Neuroscience

Phone: 608-265-7836

Address:
Mail: 5505 WIMR 2
Office: 5553 WIMR 2

Lab Website: Moore Lab

Research Interests

My lab is interested in the question of how and why somatic stem cells dysfunction with age. Throughout life, stem cells are responsible for replenishing and regenerating tissue, fundamentally maintaining “youthfulness.” With aging, this ability is lost, resulting in effects such as cognitive impairment, reduced immune response, deterioration of skeletal muscle, and difficulty in wound healing, for example. To develop methods to improve or rescue aging of somatic stem cells, we must understand not only how they age, but also how they remain young.

Recently we have shown that neural stem cells (NSCs) asymmetrically segregate cargoes (e.g. damaged proteins) when they divide, leaving one daughter cell more “clean” than the other. That daughter cell which inherits the damage has a slower proliferation rate than the more “clean” daughter, suggesting that this process may be used for cellular rejuvenation (Moore et al, 2015 Science). This asymmetric segregation is affected with age, suggesting that investigating the mechanisms and cargoes involved in this asymmetric inheritance may reveal a means to improve stem cell aging.

Honors & Awards

2020 – Vallee Scholar Award
2019 – Shaw Scientist Award
2018 – NIH Directors New Innovator Award (DP2)
2017 – American Federation for Aging (AFAR) Research Grant for Junior Faculty
2017 – Alfred P. Sloan Research Fellow in Neuroscience
2016: Society for Neuroscience (SFN) Peter and Patricia Gruber International Research Award
2012–2015: Human Frontier Science Program Long-term Postdoctoral Fellowship

Selected Publications

C.S. Morrow, T.J. Porter, N. Xu, Z.P. Arndt, K. Ako-Asare, H.J. Heo, E.A.N. Thompson, D.L. Moore (2020). Vimentin Coordinates Protein Turnover at the Aggresome during Neural Stem Cell Quiescence Exit. Cell Stem Cell, in press.
C.S. Morrow, D.L. Moore (2019). Stem cell aging? Blame it on the niche. Cell Stem Cell, Preview. 24(3): 353-354. PMID: 30849364
J. Galvao, K. Iwao, A. Apara, Y. Wang, M. Ashouri, T. Shah, M. Blackmore, N. Kunzevitzky, D.L. Moore, J.L. Goldberg (2018). The Krüppel-Like Factor Gene Target Dusp14 Regulates Axon Growth and Regeneration, IOVS, 59(7): 2736-2747. PMID: 29860460
D.L. Moore*, S. Jessberger* (2017). Creating Age Asymmetry: Consequences of Inheriting Damaged Goods in Mammalian Neural Stem Cells. Trends in Cell Biology, 27(1): 82-92. PMID: 27717533 *co-corresponding authors
R. Beckervordersandforth, B. Ebert, Schäffner I, J. Moss, C. Fiebig, J. Shin, D.L. Moore, L. Ghosh, M.F. Trinchero, C. Stockburger, K. Friedland, K. Steib, J. von Wittgenstein, S. Keiner, C. Redecker, S.M. Hölter, W. Xiang, W. Wurst, R. Jagasia, A.F. Schinder, G.L. Ming, N. Toni, S. Jessberger, H. Song, D.C. Lie (2017). Role of mitochondrial metabolism in the control of early lineage progression and aging phenotypes in adult hippocampal neurogenesis. Neuron, 93(3): 560-573. PMID: 28111078
M. Knobloch, G.A. Pilz, B. Ghesquière, W.J. Kovacs, T. Wegleiter, D.L. Moore, M. Hruzova, N. Zamboni, P. Carmeliet, S. Jessberger (2017). A fatty acid oxidation-dependent metabolic shift regulates adult neural stem cell quiescence. Cell Reports, 20(9): 2144-2155. PMID: 28854364
A. Apara, J. Galvao, Y. Wang, M. Blackmore, A. Trillo, K. Iwao, D. Brown, K. Fernandes, A. Huang, T. Nguyen, M. Ashouri, X. Zhang, P. Shaw, N. Kunzevitzky, D.L. Moore, R. Libby, and J.L. Goldberg (2017). KLF9 and JNK3 Interact to Suppress Axon Regeneration in the Adult CNS. Journal of Neuroscience, 37(40): 9632-9644. PMID: 28871032.
D.L. Moore, G.A. Pilz, M.J. Araúzo-Bravo, Y.Barral, S. Jessberger (2015). A mechanism for the segregation of age in mammalian neural stem cells. Science, 349(6254): 1334-1338. PMID: 26383951
D.L. Moore, S. Jessberger. (2013). All astrocytes are not created equal – the role of astroglia in brain injury. EMBO Reports, 14(6): 487-8. PMID: 23619094
D.L. Moore, J.L. Goldberg (2011). Multiple transcription factor families regulate axon growth and regeneration. Developmental Neurobiology, 71(12): 1186-211. PMID: 21674813
M. G. Blackmore, D. L. Moore, R. P. Smith, J. L. Goldberg, J. L. Bixby, and V. P. Lemmon (2010). High content screening of cortical neurons identifies novel regulators of axon growth. Molecular and Cellular Neuroscience, 44(1): 43-54. PMID: PMC2890283
D. L. Moore, M. G. Blackmore, Y. Hu, K. H. Kaestner, J. L. Bixby, V. P. Lemmon, and J. L. Goldberg (2009). KLF Family Members Regulate Intrinsic Axon Regeneration Ability. Science, 326(5950): 298-301. PMID: PMC2882032