Adam Schaenzer, PhD

Biography

Selected Publications

• Schaenzer AJ, Wlodarchak N, Drewry DH, Zuercher WJ, Rose WE, Ferrer CA, Sauer JD, Striker R. GW779439X and Its Pyrazolopyridazine Derivatives Inhibit the Serine/Threonine Kinase Stk1 and Act As Antibiotic Adjuvants against β-Lactam-Resistant Staphylococcus aureus. ACS Infect Dis. 2018 Aug 15. doi: 10.1021/acsinfecdis.8b00136. [Epub ahead of print] PubMed PMID: 30059625.
• Schaenzer AJ, Wlodarchak N, Drewry DH, Zuercher WJ, Rose WE, Striker R, Sauer JD. A screen for kinase inhibitors identifies antimicrobial imidazopyridine aminofurazans as specific inhibitors of the Listeria monocytogenes PASTA kinase PrkA. J Biol Chem. 2017 Oct 13;292(41):17037-17045. doi: 10.1074/jbc.M117.808600. Epub 2017 Aug 16. PubMed PMID: 28821610; PubMed Central PMCID: PMC5641865.
• Pensinger DA, Schaenzer AJ, Sauer JD. Do Shoot the Messenger: PASTA Kinases as Virulence Determinants and Antibiotic Targets. Trends Microbiol. 2018 Jan;26(1):56-69. doi: 10.1016/j.tim.2017.06.010. Epub 2017 Jul 19. Review. PubMed PMID: 28734616; PubMed Central PMCID: PMC5741517.
• Pensinger DA, Boldon KM, Chen GY, Vincent WJ, Sherman K, Xiong M, Schaenzer AJ, Forster ER, Coers J, Striker R, Sauer JD. The Listeria monocytogenes PASTA Kinase PrkA and Its Substrate YvcK Are Required for Cell Wall Homeostasis, Metabolism, and Virulence. PLoS Pathog. 2016 Nov 2;12(11):e1006001. doi: 10.1371/journal.ppat.1006001. eCollection 2016 Nov. PubMed PMID: 27806131; PubMed Central PMCID: PMC5091766.
• Pensinger DA, Aliota MT, Schaenzer AJ, Boldon KM, Ansari IU, Vincent WJ, Knight B, Reniere ML, Striker R, Sauer JD. Selective pharmacologic inhibition of a PASTA kinase increases Listeria monocytogenes susceptibility to β-lactam antibiotics. Antimicrob Agents Chemother. 2014 Aug;58(8):4486-94. doi: 10.1128/AAC.02396-14. Epub 2014 May 27. PubMed PMID: 24867981; PubMed Central PMCID: PMC4135996.