Molecular and Cellular Pharmacology Training Program
University of Wisconsin School of Medicine and Public Health

Adam Schaenzer, PhD

Position title: Postdoctoral Fellow, McMaster University, Canada

Email: aschaenzer@wisc.edu

Phone: Advisor: Dr. JD Sauer

Address:
Graduation: 9/2018
Research Interests: Understanding the role of PASTA-kinases in bacterial antibiotic resistance

Adam Schaenzer

Selected Publications

  • Schaenzer AJ, Wlodarchak N, Drewry DH, Zuercher WJ, Rose WE, Ferrer CA, Sauer
    JD, Striker R. GW779439X and Its Pyrazolopyridazine Derivatives Inhibit the
    Serine/Threonine Kinase Stk1 and Act As Antibiotic Adjuvants against
    β-Lactam-Resistant Staphylococcus aureus. ACS Infect Dis. 2018 Aug 15. doi:
    10.1021/acsinfecdis.8b00136. [Epub ahead of print] PubMed PMID: 30059625.
  • Schaenzer AJ, Wlodarchak N, Drewry DH, Zuercher WJ, Rose WE, Striker R, Sauer
    JD. A screen for kinase inhibitors identifies antimicrobial imidazopyridine
    aminofurazans as specific inhibitors of the Listeria monocytogenes PASTA kinase
    PrkA. J Biol Chem. 2017 Oct 13;292(41):17037-17045. doi: 10.1074/jbc.M117.808600.
    Epub 2017 Aug 16. PubMed PMID: 28821610; PubMed Central PMCID: PMC5641865.
  • Pensinger DA, Schaenzer AJ, Sauer JD. Do Shoot the Messenger: PASTA Kinases as
    Virulence Determinants and Antibiotic Targets. Trends Microbiol. 2018
    Jan;26(1):56-69. doi: 10.1016/j.tim.2017.06.010. Epub 2017 Jul 19. Review. PubMed
    PMID: 28734616; PubMed Central PMCID: PMC5741517.
  • Pensinger DA, Boldon KM, Chen GY, Vincent WJ, Sherman K, Xiong M, Schaenzer
    AJ, Forster ER, Coers J, Striker R, Sauer JD. The Listeria monocytogenes PASTA
    Kinase PrkA and Its Substrate YvcK Are Required for Cell Wall Homeostasis,
    Metabolism, and Virulence. PLoS Pathog. 2016 Nov 2;12(11):e1006001. doi:
    10.1371/journal.ppat.1006001. eCollection 2016 Nov. PubMed PMID: 27806131; PubMed
    Central PMCID: PMC5091766.
  • Pensinger DA, Aliota MT, Schaenzer AJ, Boldon KM, Ansari IU, Vincent WJ,
    Knight B, Reniere ML, Striker R, Sauer JD. Selective pharmacologic inhibition of
    a PASTA kinase increases Listeria monocytogenes susceptibility to β-lactam
    antibiotics. Antimicrob Agents Chemother. 2014 Aug;58(8):4486-94. doi:
    10.1128/AAC.02396-14. Epub 2014 May 27. PubMed PMID: 24867981; PubMed Central PMCID: PMC4135996.