Beth A. Weaver, PhD

Selected Publications

For a full list, visit Dr. Weaver’s PubMed page

• Scribano CM, Wan J, Esbona K, Tucker JB, Lasek A, Zhou AS, Zasadil LM, Molini R, Fitzgerald J, Lager AM, Laffin JJ, Correia-Staudt K, Wisinski KB, Tevaarwerk AJ, O’Regan R, McGregor SM, Fowler AM, Chappell RJ, Bugni TS, Burkard ME, Weaver BA. 2021. Chromosomal instability sensitizes patient breast tumors to multipolar divisions induced by paclitaxel. Sci Transl Med 13(610) eabd4811 DOI: 10.1126/scitranslmed.abd4811.
• Funk, L.C., Wan, J., Ryan, S.D., Kaur, C., Sullivan, R., Roopra, A., and Weaver, B.A. 2020. p53 is not required for high CIN to induce tumor suppression. Mol Cancer Res. doi: 10.1158/1541-7786.MCR-20-0488.
• Wan, J., Block, S., Scribano, C.M., Thiry, R. Esbona, K. Audhya, A. Weaver, B.A. 2019. Mad1 destabilizes p53 by preventing PML from sequestering MDM2. Nature Commun 10: 1540-1553.
• Burkard M.E. and Weaver B.A. 2017. Tuning chromosomal instability to optimize tumor fitness. Cancer Discov 7: 134-136.

   

• Choudhary A., Zachek B., Lera R.F., Zasadil L.M., Lasek A., Denu R.A., Kim H., Kanugh C., Laffin J., Harter J.M., Wisinski K.B., Saha S., Weaver B.A., Burkard M.E. 2016. Identification of selective lead compounds for treatment of high-ploidy breast cancer. Mol Cancer Ther. 15:48-59.
• Denu R.A., Zasadil L.M., Kanugh C., Laffin J., Weaver B.A., Burkard M.E. 2016. Centrosome amplification induces high grade features and is prognostic of worse outcomes in breast cancer. BMC Cancer Jan 29;16:47.
• Zasadil L.M., Britigan E.M.C., Ryan S.D., Kaur C., Guckenberger D.J., Beebe, D.J., Moser A.R., Weaver B.A. 2016. High rates of chromosome missegregation suppress tumor progression, but do not inhibit tumor initiation. Mol Biol Cell 27: 1981-9. This work was highlighted on the cover of the issue and by the American Society for Cell Biology.
• Cunningham C.E., Li S., Vizeacoumar F.S., Bhanumathy K.K., Lee J.S., Parameswaran S., Furber L., Abuhussein O., Paul J.M., McDonald M., Templeton S.D., Shukla H., El Zawily A.M., Boyd F., Alli N., Mousseau D.D., Geyer R., Bonham K., Anderson D.H., Yan J., Yu-Lee L.Y., Weaver B.A., Uppalapati M., Ruppin E., Sablina A., Freywald A. Vizeacoumar F.J. 2016. Therapeutic relevance of the protein phosphatase 2A in cancer. Oncotarget 7:61544-61561.
• Funk L.C., Zasadil L.M., Weaver B.A. 2016. Living in CIN: Mitotic infidelity and its consequences for tumor promotion and suppression. Dev Cell 39: 638-652.
• Hwang B, McCool K, Wan J, Wuerzberger-Davis SM, Young EW, Choi EY, Cingolani G, Weaver BA, Miyamoto S. IPO3 mediated nonclassical nuclear import of NEMO drives DNA damage-dependent NF-κB activation. J Biol Chem. 2015 Jun 9. pii: jbc.M115.645960.
• Zasadil LM, Andersen K, Ryan SD, Yeum D, Raines R, Burkard ME, and Weaver BA (2014). Cytotoxicity of paclitaxel in breast cancer is due to chromosome missegregation on multipolar spindles. Science Translational Medicine 6:229ra43. (This work was selected for F1000 Prime and highlighted on the cover of the issue, in Science News and in Cancer Discovery News.
• Weaver, B.A. 2014. How Taxol/paclitaxel kills cancer cells. Mol Biol Cell 25:2677-81.
• Britigan, E.M.C., Wan, J., Zasadil, L.M., Ryan, S.D. and Weaver, B.A.  2014. The ARF tumor suppressor prevents chromosomal instability and ensures mitotic checkpoint fidelity through regulation of Aurora B. Mol Biol Cell 25:2761-73. (This work was highlighted by the American Society for Cell Biology)
• Wan, J., Zhu, F., Zasadil, L.M., Yu, J., Wang, L., Johnson, A., Berthier, E., Beebe, D.J., Audhya A. and Weaver, B. A. 2014. Golgi localized pool of the mitotic checkpoint component Mad1 controls integrin secretion and cell migration, Curr Biol 24: 2687–2692. (This work was highlighted in Science Signaling.)