Lauren Zasadil, PhD
Howard Hughes Medical Institute Fellow of the Helen Hay Whitney Foundation, Amon Lab, Massachusetts Institute of Technology
Advisor: Dr. Beth Weaver
Graduation: 12/2015
Biography
Alumni News
Dr. Zasadil was selected as a Howard Hughes Medical Institute Fellow of the Helen Hay Whitney Foundation starting in September 2017.Publications
- Zasadil LM, Andersen KA, Yeum D, Rocque GB, Wilke LG, Tevaarwerk AJ, Raines RT, Burkard ME, Weaver BA. Cytotoxicity of paclitaxel in breast cancer is due to chromosome missegregation on multipolar spindles. Sci Transl Med. 2014 Mar 26;6(229):229ra43. doi: 10.1126/scitranslmed.3007965. PubMed PMID: 24670687; PubMed Central PMCID: PMC4176609.
- Denu RA, Zasadil LM, Kanugh C, Laffin J, Weaver BA, Burkard ME. Centrosome amplification induces high grade features and is prognostic of worse outcomes in breast cancer. BMC Cancer. 2016 Jan 29;16:47. doi: 10.1186/s12885-016-2083-x. PubMed PMID: 26832928; PubMed Central PMCID: PMC4734858.
- Zasadil LM, Britigan EM, Weaver BA. 2n or not 2n: Aneuploidy, polyploidy and chromosomal instability in primary and tumor cells. Semin Cell Dev Biol. 2013 Apr;24(4):370-9. doi: 10.1016/j.semcdb.2013.02.001. Epub 2013 Feb 13. PubMed PMID: 23416057; PubMed Central PMCID: PMC3736819.
- Britigan EM, Wan J, Zasadil LM, Ryan SD, Weaver BA. The ARF tumor suppressor prevents chromosomal instability and ensures mitotic checkpoint fidelity through regulation of Aurora B. Mol Biol Cell. 2014 Sep 15;25(18):2761-73. doi: 10.1091/mbc.E14-05-0966. Epub 2014 Jul 23. PubMed PMID: 25057018; PubMed Central PMCID: PMC4161511.
- Zasadil LM, Britigan EM, Ryan SD, Kaur C, Guckenberger DJ, Beebe DJ, Moser AR, Weaver BA. High rates of chromosome missegregation suppress tumor progression but do not inhibit tumor initiation. Mol Biol Cell. 2016 Jul 1;27(13):1981-9. doi: 10.1091/mbc.E15-10-0747. Epub 2016 May 4. PubMed PMID: 27146113; PubMed Central PMCID: PMC4927272.
- Wan J, Zhu F, Zasadil LM, Yu J, Wang L, Johnson A, Berthier E, Beebe DJ, Audhya A, Weaver BA. A Golgi-localized pool of the mitotic checkpoint component Mad1 controls integrin secretion and cell migration. Curr Biol. 2014 Nov 17;24(22):2687-92. doi: 10.1016/j.cub.2014.09.052. Epub 2014 Oct 23. PubMed PMID: 25447996; PubMed Central PMCID: PMC4254593.
- Choudhary A, Zachek B, Lera RF, Zasadil LM, Lasek A, Denu RA, Kim H, Kanugh C, Laffin JJ, Harter JM, Wisinski KB, Saha S, Weaver BA, Burkard ME. Identification of Selective Lead Compounds for Treatment of High-Ploidy Breast Cancer. Mol Cancer Ther. 2016 Jan;15(1):48-59. doi: 10.1158/1535-7163.MCT-15-0527. Epub 2015 Nov 19. PubMed PMID: 26586723; PubMed Central PMCID: PMC4707107.
- Ryan SD, Britigan EM, Zasadil LM, Witte K, Audhya A, Roopra A, Weaver BA. Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisons. Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):E2205-14. doi: 10.1073/pnas.1201911109. Epub 2012 Jul 9. PubMed PMID: 22778409; PubMed Central PMCID: PMC3421180.
- Silk AD, Zasadil LM, Holland AJ, Vitre B, Cleveland DW, Weaver BA. Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors. Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):E4134-41. doi: 10.1073/pnas.1317042110. Epub 2013 Oct 16. PubMed PMID: 24133140; PubMed Central PMCID: PMC3816416.
- Yoo SK, Lam PY, Eichelberg MR, Zasadil L, Bement WM, Huttenlocher A. The role of microtubules in neutrophil polarity and migration in live zebrafish. J Cell Sci. 2012 Dec 1;125(Pt 23):5702-10. doi: 10.1242/jcs.108324. Epub 2012 Sep 19. PubMed PMID: 22992461; PubMed Central PMCID: PMC3575705.
- Funk LC, Zasadil LM, Weaver BA. Living in CIN: Mitotic Infidelity and Its Consequences for Tumor Promotion and Suppression. Dev Cell. 2016 Dec 19;39(6):638-652. doi: 10.1016/j.devcel.2016.10.023. Review. PubMed PMID: 27997823; PubMed Central PMCID: PMC5204306.