Lihong Zhan, PhD
Senior Scientist, Denali Therapeutics, San Francisco, CA
Advisor: Dr. Randal Tibbetts
Graduation: 12/2014
Research Interest: Lessons from a drosophila model of ALS, where MAPK signaling, oxidative stress, and neuroinflammation intersect in TDP-43 induced neuropathogenesis
Biography
Publications
- Zhan L, Xie Q, Tibbetts RS. Opposing roles of p38 and JNK in a Drosophila model of TDP-43 proteinopathy reveal oxidative stress and innate immunity as pathogenic components of neurodegeneration. Hum Mol Genet. 2015 Feb 1;24(3):757-72. doi: 10.1093/hmg/ddu493. Epub 2014 Oct 3. PubMed PMID: 25281658; PubMed Central PMCID: PMC4291250.
- Zhan L, Hanson KA, Kim SH, Tare A, Tibbetts RS. Identification of genetic modifiers of TDP-43 neurotoxicity in Drosophila. PLoS One. 2013;8(2):e57214. doi: 10.1371/journal.pone.0057214. Epub 2013 Feb 27. PubMed PMID: 23468938; PubMed Central PMCID: PMC3584124.
- Kim SH, Zhan L, Hanson KA, Tibbetts RS. High-content RNAi screening identifies the Type 1 inositol triphosphate receptor as a modifier of TDP-43 localization and neurotoxicity. Hum Mol Genet. 2012 Nov 15;21(22):4845-56. doi: 10.1093/hmg/dds321. Epub 2012 Aug 7. PubMed PMID: 22872699; PubMed Central PMCID: PMC3529575.
- Shanware NP, Hutchinson JA, Kim SH, Zhan L, Bowler MJ, Tibbetts RS. Casein kinase 1-dependent phosphorylation of familial advanced sleep phase syndrome-associated residues controls PERIOD 2 stability. J Biol Chem. 2011 Apr 8;286(14):12766-74. doi: 10.1074/jbc.M111.224014. Epub 2011 Feb 15. PubMed PMID: 21324900; PubMed Central PMCID: PMC3069476.
- Shanware NP, Zhan L, Hutchinson JA, Kim SH, Williams LM, Tibbetts RS. Conserved and distinct modes of CREB/ATF transcription factor regulation by PP2A/B56gamma and genotoxic stress. PLoS One. 2010 Aug 13;5(8):e12173. doi: 10.1371/journal.pone.0012173. PubMed PMID: 20730097; PubMed Central PMCID: PMC2921338.