2005 Signal Transduction Research Training Symposium

September 29, 2005 : Fluno Center, Madison, WI

Keynote Speaker

“Dynamics in Drug Design: Fluctuations in Target Structure and Freeze-Frame Inhibitors in the Cholinergic Nervous System”

Dr. Palmer W. Taylor
Professor and Chair, Department of Pharmacology
University of California, San Diego
School of Medicine

Dr. Taylor’s laboratory is interested in the structure and function of enzymes and receptors involved in neurotransmission. In particular, the functional coupling of receptors to cellular responses, specificity of ligand recognition by acetylcholine receptors and acetylcholinesterase, and the structures of cholinesterases and nicotinic acetylcholine receptors. A second area of investigation involves the regulation of expression of the genes encoding these proteins during differentiation and synaptogenesis in neurons and skeletal muscle.


Continental Breakfast – Upstairs Foyer (2nd floor)
Registration is Necessary

Dr. Patricia J. Keely – Chair, Symposium Committee
Assistant Professor, Department of Pharmacology

Morning Session Chair: Dr. Richard A. Anderson

PIASy is a SUMO Ligase for NEMO Critical for NF-kB Activation by Genotoxic Stress
Angela M. Mabb
Dr. Shigeki Miyamoto
Molecular and Cellular Pharmacology Program

Dominant Negative PKC-e Inhibits Ventricular Myocytes Responses to Endothelin-1
Misuk Kang
Dr. Jeffery W. Walker
Molecular and Cellular Pharmacology Program

Selection and Characterization of Ligand Regulated Peptide Aptamers that Inhibit the 5’AMP-Activated Protein Kinase
Russell Miller
Dr. Peter J. Belshaw
Biochemistry Department

6-Hydroxydopamine Activates the Antioxidant Response Element Through a Combination of Oxidative, Excitotoxic, and Potential Structural Factors
Rebekah Jakel
Dr. Jeffrey A. Johnson
Neuroscience Training Program, MSTP Program

Poster Session and Coffee Break – Main Lobby

Keynote Address: Dynamics in Drug Design: Fluctuations in Target Structure and Freeze-Frame Inhibitors in the Cholinergic Nervous System
Dr. Palmer W. Taylor
Founding Dean, School of Pharmacy &
Pharmaceutical Sciences
University of California, San Diego

Lunch – Main Floor Dining Room

Afternoon Session Chair: Dr. Cynthia M. Czajkowski

Disruption of b2 K102-T110, a Region that Links the GABA-A Receptor’s Agonist Binding Site to the Inner b-sheet Domain, Impairs Channel Activation
Srinivasan P Venkatachalan
Dr. Cynthia Czjakowski
Physiology Department


Regulation of Adhesion Dynamics by the Adaptor Protein, RACK1
Ashley Doan
Dr. Anna Huttenlocher
Molecular and Cellular Pharmacology

Ligand-Induced Conformational Transitions in the GABAA Receptor Probed with Site-Specific Fluorescent Labels
Yukiko Muroi
Meyer Jackson
Molecular and Cellular Pharmacology Program

Nuclear Phosphatidylinositol 4,5-Bisphosphate and Pre-mRNA Splicing
Michael L. Gonzales
Richard A. Anderson
Molecular and Cellular Pharmacology Program

Poster Session and Reception – Main Lobby