Chris Morrow (Moore lab) recently published an article in Cell Stem Cell called “Vimentin Coordinates Protein Turnover at the Aggresome during Neural Stem Cell Quiescence Exit”.
Recent evidence suggests that neural stem cell (NSC) quiescence exit is a significant barrier to adult neurogenesis. Morrow et al. reveal that NSCs rely on vimentin-mediated proteasome localization to the aggresome to clear proteins during quiescence exit and uncover a critical role of vimentin as a regulator of cellular proteostasis.
Citation: Morrow et al., Vimentin Coordinates Protein Turnover at the Aggresome during Neural Stem Cell Quiescence Exit, Cell Stem Cell (2020), https://doi.org/10.1016/j.stem.2020.01.018