University of Wisconsin School of Medicine and Public Health
Biography Research Interests Our research is aimed at understanding the cellular and molecular mechanisms that regulate cell migration, and how defects in cell migration contribute to human disease. We use both in vitro approaches including cell culture systems and human studies, and in vivo studies using zebrafish as a genetic model system. Cell migration plays …
Lab Website Johannsen Lab Biography Research Interests Our research focuses on the molecular biology of Epstein-Barr virus (EBV) nuclear proteins, their role in the virus lifecycle and the pathogenesis of EBV associated malignancies. Herpesviruses infect their hosts for life and EBV precisely manipulates growth and survival signaling pathways of B lymphocytes, resulting in their immortalization. …
Biography Research Interests Cardiovascular Calcium Channels Function, Structure and Regulation. Cardiac Ca2+ channels play an important role in cellular excitability by allowing the rapid influx of Ca which depolarizes the cell. The resulting increase in intracellular [Ca2+] is essential for regulation of Ca2+-dependent processes including excitation-contraction coupling, excitation- secretion coupling, and gene regulation. Current research …
Lab Website Kimple Lab Biography Research Description Research in the Michelle Kimple lab is focused on how the endocrine cells of the pancreatic islet of Langerhans coordinate to regulate hormone secretion in response to glucose and other stimuli; impacting whole-body fuel metabolism. The Kimple Lab is especially interested in elucidating how G protein signaling networks …
Biography Research Interests Single-domain antibody engineering Targeted radionuclide therapy and nuclear imaging Antibody-drug conjugates Strucutral biology The LeBeau laboratory operates at the interface of synthetic biology and nuclear medicine. Our goal is to decrease cancer mortality and morbidity by developing antibody‑based molecular imaging agents and targeted therapeutics. We are pioneering the use of Variable New …
Lab Website Li Research Group Biography Research Interests Neuropeptides are an important class of signaling molecules and can act as drugs. Currently relatively little is known about neuropeptides and the technology available today is not sufficient to address many of the challenges. This is a promising area that needs both new technologies and creative insight …
Biography Research Description Project 1: How do DNA viruses localize to cellular sites of DNA damage? We are interested in understanding how viruses localize to distinct cellular sites within the host cell’s nucleus. We have adapted high throughput chromosome conformation capture-based methods to map the sites in host cells where the viral genome can localize. …
Biography Research Interests We study JAK inhibitors in Sjogren’s Disease. Our past work focused on the effect of a specific JAK 1/2 inhibitor on fibroblasts cultured in vitro. Our submitted work focuses on the the effect of JAK inhibitor withdrawal on STAT signaling in disease. In the future, we are expanding our understanding of interferon …
Lab Website Moore Lab Biography Research Interests My lab is interested in the question of how and why somatic stem cells dysfunction with age. Throughout life, stem cells are responsible for replenishing and regenerating tissue, fundamentally maintaining “youthfulness.” With aging, this ability is lost, resulting in effects such as cognitive impairment, reduced immune response, deterioration …
Biography Research Interests The Richards Lab focuses on developing novel immunotherapies for high-risk pediatric leukemias including acute myeloid leukemia (AML). The primary focus of the lab is to optimize chimeric antigen receptor (CAR) T cell therapies and other immune effector cells. There are many reasons that CAR T cells have not been successfully implemented in …