People Type: T32 Faculty

Biography Research Interests Defining mechanisms by which diet and xenobiotics impact host-microbiota-immune dialogues with consequences for autoimmunity. Our lab is investigating the impact of diet and xenobiotics on microbiota-immune crosstalk. In previous collaborative studies, we investigated how a common drug used in treatment of autoimmune patients (methotrexate) perturbs the gut microbiome and reduces immune activation …

Biography Research Interests The long-term goal of the Alvarado Lab is to is to understand the mechanisms of heart disease and to develop safe and effective treatments that improve the life of patients. Our primary interest is the regulation of cardiac ion channels with emphasis on diseases arising from their dysfunction, especially calcium-dependent arrhythmias and …

Lab Website Audhya Lab Biography Research Interests Our laboratory is committed to understanding the fundamental mechanisms by which membrane proteins, lipids, and other macromolecules are transported throughout eukaryotic cells. To do so, we take advantage of numerous interdisciplinary approaches, including pharmacology, biochemistry, structural biology, biophysics, genetics, molecular biology and high-resolution fluorescence and electron microscopy. Additionally, …

Biography Research Interests Hematopoiesis, Blood Cancer Mechanisms and Genome/Epigenome Function The Bresnick group conducts basic and translational research on genomics/epigenomics, hematopoiesis,  myeloid/erythroid cell biology and pharmacology. We discovered GATA2 enhancers that are essential for hematopoiesis and embryonic development, and their disruption causes human diseases. Our studies unveiled paradigms to explain hematopoietic stem cell generation, progenitor …

Lab Website Bugni Lab Biography Research Interests Tim Bugni’s research interests are marine natural products chemistry, symbiotic microorganisms, drug discovery, metabolomics, and NMR and MS for structure elucidation of novel natural products. Genetically encoded small molecules, natural products, have been a valuable source of therapeutics particularly in the areas of cancer and infectious disease. However, …

Biography Research Interests Drug discovery can be a long and expensive process. To accelerate research in the development of new treatments, phenotypic approaches are used to screen compounds at high-throughput and identify promising candidates quickly. Microscopy imaging and Cell Painting have been widely adopted in industry and academia to determine the effects of drugs by …

HHMI Investigator HHMI Neuroscience Faculty Page Neuroscience Faculty Page Lab Website Chapman Lab Biography Research Description Our laboratory studies membrane trafficking and fusion in neurons; our over-arching goal is to understand presynaptic aspects of synaptic transmission and plasticity. To address these questions, our laboratory is divided into three related and highly interactive subgroups: Nanomechanics of …

Lab Website Engin Lab Biography Research Interests Autoimmune-mediated β-cell destruction is the major cause of type 1 diabetes (T1D), yet the precise molecular mechanisms by which β-cells contribute to their own demise in T1D pathogenesis remain poorly understood. Pancreatic β-cells undergo significant physiological endoplasmic reticulum (ER) stress during insulin synthesis, requiring an effective adaptive response …

Lab Website Ge Research Group Biography Research Interests Our research aims to understand the molecular and cellular mechanisms underlying cardiovascular diseases via systems biology approaches featuring cutting-edge high-resolution mass spectrometry (MS)-based comparative proteomics and metabolomics in conjunction with biochemical/biological/physiological functional studies. Our research is highly interdisciplinary within the interface of chemistry, biology, and medicine. Success …

Lab Website Glukhov Lab Biography Research Interests Our laboratory is a part of the Cellular and Molecular Arrhythmia Research Program (CMARP) involving multiple investigators working on a wide range of research projects exploring the molecular function of ion channels in human physiology, pharmacology, and disease. Our research interests are focused on studying cellular and molecular …