University of Wisconsin School of Medicine and Public Health
Biography Research Interests My laboratory does biology research in engineered tissues, at the interface of cell biology and engineering. My laboratory uses these techniques to investigate the role of the microenvironment in disease progression. Specifically, we leverage bottom-up tissue engineering strategies (including microphysiological systems) to recapitulate vascularized environments in disease states, and the role of …
Lab Website Weaver Lab Biography Research Interests Chromosome segregation during mitosis Effects of chromosome segregation missegregation on tumor initiation, progression, and response to therapy Mitotic errors induced by chemotherapy and radiation Honors & Awards 2017-2018 UWCCC Ride Scholar 2017-2022 Romnes Faculty Fellow 2015-2019 American Cancer Society Research Scholar 2010 American Cancer Society University of Wisconsin …
Biography Research Interests The Wenthur laboratory is currently exploring how the immune system can alter the function of brain reward systems, as a means to develop new therapeutics for addiction and associated psychiatric illnesses. Within this overall effort, there are multiple interconnected projects crafted to support rapid translation of these findings and improve human health. …
Lab Website Wheeler Lab Biography Research Interests The focus of my laboratory centers around the epidermal growth factor receptor (EGFR) which is ubiquitously expressed receptor tyrosine kinase (RTK). Upon ligand binding, the EGFR initiates a spectrum of signaling pathways that promote cell proliferation, differentiation, migration, motility, and cellular adhesion. The EGFR is recognized as a …
Biography Research Interests Cardiac development is precisely regulated by the interplay of several transcription factors within a network. How these transcription factors mechanistically interact and how perturbation of the transcription factor network results in congenital heart disease requires further elucidation. Through the use of advanced microscopy, single cell sequencing technologies, proteomics, and functional assays, we …
Biography Research Interests My laboratory is focused on the transcriptional regulation of estrogen receptor (ER) signaling pathways by nuclear receptor co-factors. We identified a natural plant product that significantly decreased ERa but increased ERb stability. Via distinct mechanism from the existing agents for endocrine therapy, this compound also significantly promoted degradation of mutant ERa that …
Biography Research Interests Extremely premature children face many health issues, including a strong risk of vision loss. Retinopathy of prematurity (ROP) is a leading cause of visual impairment and loss in these children, affecting more than half of the 0.72% of babies born in the United States weighing 2.75 lbs or less. ROP is driven …
Biography Research Interests Our laboratory studies neglected parasitic diseases that impose a debilitating health and economic burden throughout much of the world. These poverty associated diseases infect over 1.5 billion humans and related parasites pose a major challenge to animal and plant health. Our central ambition is to combine molecular, genetics, and pharmacological approaches to …
Lab Website Zhao Lab Biography Research Interests The molecular mechanisms that regulate neural stem cells and neurodevelopment with the goal of applying this knowledge in the treatment of neurodevelopmental disorders. Stem cells are responsible for generating all the tissues and cells of an organism during development. In adult mammals, stem cells exist in many tissues …